KCNMA1 Antikörper (AA 124-467)

Produktnummer ABIN3043867

Produktdetails anti-KCNMA1 Antikörper

Target: KCNMA1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, alpha Member 1 (KCNMA1))

Bindungsspezifität: AA 124-467

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNMA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Calcium-activated potassium channel subunit alpha-1(KCNMA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Calcium-activated potassium channel subunit alpha-1(KCNMA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Protein Name: Calcium-activated potassium channel subunit alpha-1

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human KCNMA1 recombinant protein (Position: K124-Q467). Human KCNMA1 shares 99% amino acid (aa) sequence identity with both mouse and rat KCNMA1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human, The detection limit for KCNMA1 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu KCNMA1

Target: KCNMA1 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, alpha Member 1 (KCNMA1))

Andere Bezeichnung: KCNMA1 (KCNMA1 Produkte)

Synonyme: BKTM antikoerper, KCa1.1 antikoerper, MaxiK antikoerper, SAKCA antikoerper, SLO antikoerper, SLO-ALPHA antikoerper, SLO1 antikoerper, bA205K10.1 antikoerper, mSLO1 antikoerper, DDBDRAFT_0190653 antikoerper, DDBDRAFT_0235401 antikoerper, DDB_0190653 antikoerper, DDB_0235401 antikoerper, KCNMA antikoerper, KCNMA1 antikoerper, 5730414M22Rik antikoerper, BKCa antikoerper, Slo antikoerper, Slo1 antikoerper, mSlo antikoerper, mSlo1 antikoerper, KCNMA1b antikoerper, KCNMA1c antikoerper, Kcnma antikoerper, bktm antikoerper, kcnma1-A antikoerper, sakca antikoerper, cSlo antikoerper, slo1 antikoerper, kcnma1 antikoerper, si:ch211-39f22.2 antikoerper, BcDNA:GH10751 antikoerper, CG10693 antikoerper, Dmel\CG10693 antikoerper, Dslo antikoerper, dSlo antikoerper, dSlo1 antikoerper, dslo antikoerper, fSlo antikoerper, potassium calcium-activated channel subfamily M alpha 1 antikoerper, calcium-activated BK potassium channel, alpha subunit antikoerper, potassium large conductance calcium-activated channel, subfamily M, alpha member 1 antikoerper, potassium calcium-activated channel subfamily M alpha 1 L homeolog antikoerper, potassium large conductance calcium-activated channel, subfamily M, alpha member 1a antikoerper, calcium-activated potassium channel subunit alpha-1 antikoerper, slowpoke antikoerper, KCNMA1 antikoerper, kcnma1 antikoerper, Kcnma1 antikoerper, kcnma1.L antikoerper, kcnma1a antikoerper, LOC100454095 antikoerper, slo antikoerper

Hintergrund: Calcium-activated potassium channel subunit alpha-1 also known as KCa1.1, or BK channel for short, is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized by their large conductance of potassium ions (K+) through cell membranes. This gene is located on 10q22.3. BK channels are activated (opened) by changes in membrane electrical potential and/or by increases in concentration of intracellular calcium ion (Ca2+). It is essential for the regulation of several key physiological processes including smooth muscle tone and neuronal excitability. BK channels also contribute to the behavioral effects of ethanol in the worm C. elegans under high concentrations (> 100 mM, or approximately 0.50 % BAC).It remains to be determined if BK channels contribute to intoxication in humans.

Synonyms: subfamily M subunit alpha-1 antibody|bA205K10.1 antibody|BK channel antibody|BKCA alpha antibody|BKCA alpha subunit antibody|BKTM antibody|Calcium activated potassium channel subfamily M subunit alpha 1 antibody|Calcium activated potassium channel subunit alpha 1 antibody|Calcium-activated potassium channel antibody|Calcium-activated potassium channel subunit alpha-1 antibody|DKFZp686K1437 antibody|Drosophila slowpoke like antibody|hSlo antibody|K(VCA)alpha antibody|KCa1.1 antibody|KCMA1_HUMAN antibody|KCNMA 1 antibody|KCNMA antibody|KCNMA1 antibody|Large conductance calcium activated potassium channel subfamily M alpha member 1 antibody|Maxi K antibody|Maxi K channel antibody|Maxi Potassium channel alpha antibody|MaxiK antibody|MGC71881 antibody|OTTHUMP00000060198 antibody|OTTHUMP00000064154 antibody|OTTHUMP00000064155 antibody|OTTHUMP00000064156 antibody|OTTHUMP00000064157 antibody|OTTHUMP00000064158 antibody|OTTHUMP00000064159 antibody|OTTHUMP00000064160 antibody|OTTHUMP00000064161 antibody|OTTHUMP00000064162 antibody|OTTHUMP00000064164 antibody|OTTHUMP00000064165 antibody|Potassium large conductance calcium activated channel subfamily M alpha member 1 antibody|SAKCA antibody|Slo 1 antibody|SLO alpha antibody|SLO antibody|Slo homolog antibody|Slo-alpha antibody|Slo1 antibody|Slowpoke homolog antibody|Stretch activated Kca channel antibody

Gen-ID: 3778

UniProt: Q12791

Pathways: Regulation of Hormone Metabolic Process, Sensory Perception of Sound