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ABCC4 Antikörper (AA 1-370)

ABCC4 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043774
  • Target Alle ABCC4 Antikörper anzeigen
    ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))
    Bindungsspezifität
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-370
    Reaktivität
    • 33
    • 11
    • 9
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 26
    • 4
    • 3
    • 2
    Kaninchen
    Klonalität
    • 29
    • 6
    Polyklonal
    Konjugat
    • 22
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ABCC4 Antikörper ist unkonjugiert
    Applikation
    • 18
    • 16
    • 9
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
    Protein Name: Multidrug resistance-associated protein 4
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human MRP4 recombinant protein (Position: M1-P370).
    Isotyp
    IgG
    Top Product
    Discover our top product ABCC4 Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for MRP4 is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))
    Andere Bezeichnung
    ABCC4 (ABCC4 Produkte)
    Synonyme
    EST170205 antikoerper, MOAT-B antikoerper, MOATB antikoerper, MRP4 antikoerper, D630049P08Rik antikoerper, Mrp4 antikoerper, ATP binding cassette subfamily C member 4 antikoerper, multidrug resistance-associated protein 4 antikoerper, ATP-binding cassette, sub-family C (CFTR/MRP), member 4 antikoerper, ABCC4 antikoerper, LOC515333 antikoerper, LOC616707 antikoerper, LOC695407 antikoerper, abcc4 antikoerper, Abcc4 antikoerper
    Hintergrund
    ABCC4(Atp-binding cassette, subfamily c, member 4) also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

    Synonyms: ABCC 4 antibody|ABCC4 antibody|ATP binding cassette sub family C (CFTR/MRP) member 4 antibody|ATP binding cassette sub family C member 4 antibody|ATP-binding cassette sub-family C member 4 antibody|bA464I2.1 (ATP binding cassette, sub-family C (CFTR/MRP) member 4) antibody|bA464I2.1 antibody|Canalicular multispecific organic anion transporter ABC superfamily antibody|canalicular multispecific organic anion transporter antibodyEST170205 antibody|MOAT B antibody|MOAT-B antibody|MOATB antibody|MRP 4 antibody|MRP/cMOAT related ABC transporter antibody|MRP/cMOAT-related ABC transporter antibody|MRP4_HUMAN antibody|Multi specific organic anion transporter B antibody|Multi-specific organic anion transporter B antibody|Multidrug resistance associated protein 4 antibody|Multidrug resistance-associated protein 4 antibody|OTTHUMP00000018560 antibody
    Gen-ID
    10257
    UniProt
    O15439
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