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P2RX2 Antikörper (AA 139-471)

P2RX2 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043588
  • Target Alle P2RX2 Antikörper anzeigen
    P2RX2 (Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2))
    Bindungsspezifität
    • 13
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 139-471
    Reaktivität
    • 49
    • 22
    • 16
    • 11
    • 11
    • 10
    • 10
    • 9
    • 9
    • 6
    • 3
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 50
    • 1
    • 1
    Kaninchen
    Klonalität
    • 51
    • 1
    Polyklonal
    Konjugat
    • 34
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser P2RX2 Antikörper ist unkonjugiert
    Applikation
    • 42
    • 16
    • 14
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for P2X purinoceptor 2(P2RX2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for P2X purinoceptor 2(P2RX2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: purinergic receptor P2X, ligand gated ion channel, 2
    Protein Name: P2X purinoceptor 2
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human P2X2 recombinant protein (Position: D139-L471). Human P2X2 shares 84% amino acid (aa) sequence identity with both mouse and rat P2X2.
    Isotyp
    IgG
    Top Product
    Discover our top product P2RX2 Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for P2X2 is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Meng, Zheng, Yan, Li, Fang, Li: "P2X2 and P2X5 Receptors Mediate Bladder Hyperesthesia in ICC in Female Overactive Bladder." in: Cell biochemistry and biophysics, Vol. 72, Issue 2, pp. 375-83, (2016) (PubMed).

    Lin, Li, Den, Xu, Liu, Gao, Liu, Zhang, Li, Liang: "VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X?(/)? receptor of primary sensory neurons." in: Brain research bulletin, Vol. 83, Issue 5, pp. 284-91, (2010) (PubMed).

  • Target
    P2RX2 (Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2))
    Andere Bezeichnung
    P2RX2 (P2RX2 Produkte)
    Synonyme
    DFNA41 antikoerper, P2X2 antikoerper, P2X2a antikoerper, P2x2 antikoerper, p2xr2 antikoerper, P2RX2 antikoerper, purinergic receptor P2X 2 antikoerper, purinergic receptor P2X, ligand-gated ion channel, 2 antikoerper, P2RX2 antikoerper, P2rx2 antikoerper, p2rx2 antikoerper
    Hintergrund
    The P2RX2 gene encodes the P2X2 receptor, which assembles as a trimer to form a ligand-gated ion channel gated by extracellular ATP. P2X2 receptors mediate a variety of cellular responses, including excitatory postsynaptic responses in sensory neurons. The product of this gene belongs to the family of purinoceptors for ATP. P2RX2 is mapped to 12q24.33. It has been found that ATP-activated P2RX2 influenced OHC electromotility, a stimulus-induced change in hair cell length that functions as an amplifier to determine hearing sensitivity and frequency selectivity. What's more, P2RX2 channels were necessary for development of the temporary threshold shift.

    Synonyms: ATP receptor antibody|MGC129601 antibody|P2RX 2 antibody|P2RX2 antibody|P2RX2_HUMAN antibody|P2X purinoceptor 2 antibody|P2X Receptor subunit 2 antibody|P2X2 antibody|P2X2a antibody|Purinergic receptor antibody|Purinergic receptor P2X ligand gated ion channel 2 antibody|Purinergic receptor P2X2 isoform A antibody|Purinergic receptor P2X2 isoform B antibody|Purinergic receptor P2X2 isoform C antibody|Purinergic receptor P2X2 isoform D antibody|Purinergic receptor P2X2 isoform H antibody|Purinergic receptor P2X2 isoform I antibody
    Gen-ID
    22953
    Pathways
    Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity
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