COL3A1 Antikörper (C-Term)

Produktnummer ABIN3043522

Produktdetails anti-COL3A1 Antikörper

Target: COL3A1 (Collagen, Type III, alpha 1 (COL3A1))

Bindungsspezifität: AA 1200-1221, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COL3A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Collagen alpha-1(III) chain(COL3A1) detection. Tested with WB in Human.

Sequenz: VGAAAIAGIG GEKAGGFAPY YG

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Collagen alpha-1(III) chain(COL3A1) detection. Tested with WB in Human.
Gene Name: collagen, type III, alpha 1
Protein Name: Collagen alpha-1(III) chain

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen III(1200-1221aa VGAAAIAGIGGEKAGGFAPYYG), different from the related mouse sequence by four amino acids, and from the related rat sequence by five amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Collagen III is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-COL3A1 Antikörper (ABIN3043522)

Guo, Lin, Shao, Rong, Zhang: "BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1957-1963, (2018) (PubMed).

Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).

Chen, Kong, Liu, Gao, Zhang, Li, Liu: "In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse." in: International journal of molecular medicine, Vol. 38, Issue 1, pp. 95-104, (2017) (PubMed).

et al.: "Erratum: Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway ..." in: International journal of nanomedicine, Vol. 12, pp. 1515, (2017) (PubMed).

Zhang, Wang, Cui, Zhang, Liu, Chu, Liu, Zhang, Chu: "Continuing treatment with Salvia miltiorrhiza injection attenuates myocardial fibrosis in chronic iron-overloaded mice." in: PLoS ONE, Vol. 10, Issue 4, pp. e0124061, (2016) (PubMed).

Su, Wei, Wei, Liu, Li: "Effects of rhBNP on myocardial fibrosis after myocardial infarction in rats." in: International journal of clinical and experimental pathology, Vol. 8, Issue 6, pp. 6407-15, (2016) (PubMed).

Yao, Liu, Li, Hao: "Silica promotes the transdifferentiation of rat circulating fibrocytes in vitro." in: Molecular medicine reports, Vol. 12, Issue 4, pp. 5828-36, (2016) (PubMed).

Shan, Zhou, Xia, Qian: "Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting tubular epithelial-mesenchymal transition in vivo and in vitro." in: Experimental and therapeutic medicine, Vol. 11, Issue 5, pp. 1611-1616, (2016) (PubMed).

Zhao, Liu, Shi, Xie, Cui, Li, Li, Ren: "Role of rat autologous skin fibroblasts and mechanism underlying the repair of depressed scars." in: Experimental and therapeutic medicine, Vol. 12, Issue 2, pp. 945-950, (2016) (PubMed).

Yang, Ni, Duan, Wang, Chen, Chen, Chaugai, Zeldin, Tang, Wang: "CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages." in: Prostaglandins & other lipid mediators, Vol. 116-117, pp. 64-75, (2015) (PubMed).

Xu, Zhang, Xu, Guo, Wang, Wu, Wang, Luo, Zhou: "Antiphotoaging effect of conditioned medium of dedifferentiated adipocytes on skin in vivo and in vitro: a mechanistic study." in: Stem cells and development, Vol. 24, Issue 9, pp. 1096-111, (2015) (PubMed).

Yan, Zhang, Kolkin, Wang, Xia, Fan: "Mechanisms of nerve capping technique in prevention of painful neuroma formation." in: PLoS ONE, Vol. 9, Issue 4, pp. e93973, (2015) (PubMed).

Ye, Wang, Zhang, Song, Yang, Li, Li, Su, Yang, Ma: "Over-expression of calpastatin inhibits calpain activation and attenuates post-infarction myocardial remodeling." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120178, (2015) (PubMed).

Li, Kong, Ma, Gao, Ma: "Uighur medicine abnormal savda munzip (ASMq) suppresses expression of collagen and TGF-β1 with concomitant induce Smad7 in human hypertrophic scar fibroblasts." in: International journal of clinical and experimental medicine, Vol. 8, Issue 6, pp. 8551-60, (2015) (PubMed).

Han, Wang, Wang, Li, Zang: "Association between pelvic organ prolapse and stress urinary incontinence with collagen." in: Experimental and therapeutic medicine, Vol. 7, Issue 5, pp. 1337-1341, (2014) (PubMed).

Ge, Wang, Wu, Fan, Chen, Zhu: "?-catenin is overexpressed in hepatic fibrosis and blockage of Wnt/?-catenin signaling inhibits hepatic stellate cell activation." in: Molecular medicine reports, Vol. 9, Issue 6, pp. 2145-51, (2014) (PubMed).

Zhao, Xia, Zhao, Li, Bi, Zhu, Qiao, Cheng: "Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats." in: International journal of biological sciences, Vol. 10, Issue 1, pp. 80-9, (2014) (PubMed).

Zhang, Zhang, Xie, Gao, Ma, Yuan, Li, Wang, Li, Zhang, Chu: "Multitargeted inhibition of hepatic fibrosis in chronic iron-overloaded mice by Salvia miltiorrhiza." in: Journal of ethnopharmacology, Vol. 148, Issue 2, pp. 671-81, (2013) (PubMed).

Li, Han, Li, Wang, Hu: "Effect of farnesyltransferase inhibition on cardiac remodeling in spontaneously hypertensive rats." in: International journal of cardiology, Vol. 168, Issue 4, pp. 3340-7, (2013) (PubMed).

Guo, Xu, He, Liang, Duan, Li: "Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-? expression and inhibition of PI3K/Akt pathway." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 56, pp. 436-42, (2013) (PubMed).

Details zu COL3A1

Target: COL3A1 (Collagen, Type III, alpha 1 (COL3A1))

Andere Bezeichnung: COL3A1 (COL3A1 Produkte)

Synonyme: EDS4A antikoerper, AW550625 antikoerper, Col3a-1 antikoerper, MMS10-W antikoerper, Ms10w antikoerper, mKIAA4231 antikoerper, col3a1 antikoerper, collagen type III alpha 1 chain antikoerper, collagen, type III, alpha 1 antikoerper, collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) S homeolog antikoerper, COL3A1 antikoerper, Col3a1 antikoerper, col3a1 antikoerper, col3a1.S antikoerper

Hintergrund: COL3A1, also called EDS4A or Collagen alpha-1(III), is a protein that in humans is encoded by the COL3A1 gene, it is mapped to 2q32.2. COL3A1 chain is a fibrillar-forming collagen comprising 3 alpha-1(III) chains and is expressed in early embryos and throughout embryogenesis. In adult, COL3A1 is a major component of the extracellular matrix in a variety of internal organs and skin. COL3A1 is also a fibrous scleroprotein in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue. It is involved in regulation of cortical development, and it Is the major ligand of GPR56 in the developing brain.COL3A1 binding to GPR56 can inhibit neuronal migration and activate the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12

Synonyms: CO3A1_HUMAN antibody|COL 3A1 antibody|COL3A1 antibody|Collagen alpha 1(III) chain antibody|Collagen alpha-1(III) chain antibody|Collagen III alpha 1 chain precursor antibody|Collagen III alpha 1 polypeptide antibody|Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant) antibody|Collagen type III alpha 1 antibody|Collagen type III alpha antibody|EDS4A antibody|Ehlers Danlos syndrome type IV, autosomal dominant antibody|Fetal collagen antibody|Type III collagen antibody

Gen-ID: 1281

UniProt: P02461

Pathways: Autophagie, Growth Factor Binding