Claudin 5 Antikörper (C-Term)

Produktnummer ABIN3043521

Produktdetails anti-Claudin 5 Antikörper

Target: Claudin 5 (CLDN5)

Bindungsspezifität: AA 191-218, C-Term

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Claudin-5(CLDN5) detection. Tested with WB in Human,Rat.

Sequenz: RPDLSFPVKY SAPRRPTATG DYDKKNYV

Kreuzreaktivität (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Claudin-5(CLDN5) detection. Tested with WB in Human,Rat.
Gene Name: claudin 5
Protein Name: Claudin-5

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Claudin 5(191-218aa RPDLSFPVKYSAPRRPTATGDYDKKNYV), different from the related mouse sequence by three amino acids and from the related rat sequence by four amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, The detection limit for Claudin 5 is approximately 0.2 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-Claudin 5 Antikörper (ABIN3043521)

Cen, Liu, Li, He, Wang, Liu, Liu, Ji: "Alteration in P-glycoprotein at the blood-brain barrier in the early period of MCAO in rats." in: The Journal of pharmacy and pharmacology, Vol. 65, Issue 5, pp. 665-72, (2013) (PubMed).

Details zu Claudin 5

Target: Claudin 5 (CLDN5)

Andere Bezeichnung: CLDN5 (CLDN5 Produkte)

Synonyme: AWAL antikoerper, BEC1 antikoerper, CPETRL1 antikoerper, TMVCF antikoerper, cld5 antikoerper, awal antikoerper, bec1 antikoerper, claudin-5 antikoerper, cpetrl1 antikoerper, tmvcf antikoerper, AI854493 antikoerper, MBEC1 antikoerper, Tmvcf antikoerper, cldn5 antikoerper, zgc:85723 antikoerper, zgc:103419 antikoerper, claudin 5 antikoerper, Claudin-5 antikoerper, claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) antikoerper, claudin 5a antikoerper, claudin 5b antikoerper, claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) L homeolog antikoerper, CLDN5 antikoerper, cld5 antikoerper, cldn5 antikoerper, Cldn5 antikoerper, cldn5a antikoerper, cldn5b antikoerper, cldn5.L antikoerper

Hintergrund: Claudin-5(CLDN5) also known as BEC1, is a protein that in humans is encoded by the CLDN5 gene. By use of yeast artificial chromosomes, Claudin-5 is localized between polymorphic markers D22S944 and D22S941 on chromosome 22q11, both of which are deleted in more than 80 % of VCFS patients. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. What's more, it plays a major role in tight junction-specific obliteration of the intercellular space.

Synonyms: Androgen withdrawal and apoptosis induced protein RVP1 like antibody|AWAL antibody|BEC 1 antibody|BEC1 antibody|Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) antibody|Claudin-5 antibody|Claudin5 antibody|CLD5_HUMAN antibody|CLDN 5 antibody|CLDN5 antibody|CPETR L1 antibody|CPETRL 1 antibody|CPETRL1 antibody|TMDVCF antibody|TMVCF antibody|Transmembrane protein deleted in VCFS antibody|Transmembrane protein deleted in velocardiofacial syndrome antibody

Gen-ID: 7122

UniProt: O00501

Pathways: Hepatitis C