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APH1A Antikörper (C-Term)

APH1A Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043504
  • Target Alle APH1A Antikörper anzeigen
    APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
    Bindungsspezifität
    • 16
    • 14
    • 8
    • 8
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 236-265, C-Term
    Reaktivität
    • 55
    • 35
    • 19
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 60
    • 1
    Kaninchen
    Klonalität
    • 61
    Polyklonal
    Konjugat
    • 21
    • 7
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser APH1A Antikörper ist unkonjugiert
    Applikation
    • 52
    • 37
    • 14
    • 14
    • 13
    • 13
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Gamma-secretase subunit APH-1A(APH1A) detection. Tested with WB in Human,Mouse.
    Sequenz
    LRSIQRSLLC RRQEDSRVMV YSALRIPPED
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Gamma-secretase subunit APH-1A(APH1A) detection. Tested with WB in Human,Mouse.
    Gene Name: APH1A gamma secretase subunit
    Protein Name: Gamma-secretase subunit APH-1A
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human APH1a (236-265aa LRSIQRSLLCRRQEDSRVMVYSALRIPPED), different from the related mouse sequence by one amino acid.
    Isotyp
    IgG
    Top Product
    Discover our top product APH1A Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, The detection limit for APH1a is approximately 0.1 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))
    Andere Bezeichnung
    APH1A (APH1A Produkte)
    Synonyme
    6530402N02Rik antikoerper, APH-1 antikoerper, APH-1A antikoerper, CGI-78 antikoerper, RGD1311546 antikoerper, APH-1a antikoerper, aph-1 homolog A, gamma-secretase subunit antikoerper, aph-1 homolog A, gamma secretase subunit L homeolog antikoerper, aph-1 homolog A, gamma secretase subunit antikoerper, anterior pharynx defective 1 homolog A (C. elegans) antikoerper, aph1 homolog A, gamma secretase subunit antikoerper, acylamino-acid-releasing enzyme-like antikoerper, APH1A antikoerper, aph1a.L antikoerper, Aph1a antikoerper, LOC100219182 antikoerper
    Hintergrund
    APH1a encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.

    Synonyms: 6530402N02Rik antibody|AL138795.3 antibody|Anterior Pharynx Defective 1 antibody|Anterior pharynx defective 1 homolog A antibody|APH 1A antibody|Aph 1alpha antibody|APH-1a antibody| Aph-1alpha antibody|Aph1a antibody|APH1A gamma secretase subunit antibody|APH1A_HUMAN antibody|CGI 78 antibody|CGI78 antibody|Gamma secretase subunit APH 1A antibody|Gamma Secretase Subunit APH1a antibody|Gamma-secretase subunit APH-1A antibody|Likely ortholog of C. elegans anterior pharynx defective 1A antibody|Presenilin Stabilization Factor antibody| Presenilin-stabilization factor antibody|PSF antibody|UNQ579/PRO1141 antibody
    Gen-ID
    51107
    Pathways
    Notch Signalweg, Neurotrophin Signalübertragung
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