ADAM10 Antikörper (C-Term)

Produktnummer ABIN3043163

Produktdetails anti-ADAM10 Antikörper

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Bindungsspezifität: AA 612-627, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAM10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Disintegrin and metalloproteinase domain-containing protein 10(ADAM10) detection. Tested with WB in Human.

Sequenz: SVQWSRHFSG RTITLQ

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Disintegrin and metalloproteinase domain-containing protein 10(ADAM10) detection. Tested with WB in Human.
Gene Name: ADAM metallopeptidase domain 10
Protein Name: Disintegrin and metalloproteinase domain-containing protein 10(ADAM 10)

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ADAM10(612-627aa SVQWSRHFSGRTITLQ).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-ADAM10 Antikörper (ABIN3043163)

Lin, Huang, Xie, Zhou, Yang, Huang: "Gemcitabine inhibits immune escape of pancreatic cancer by down regulating the soluble ULBP2 protein." in: Oncotarget, Vol. 7, Issue 43, pp. 70092-70099, (2018) (PubMed).

Details zu ADAM10

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Andere Bezeichnung: ADAM10 (ADAM10 Produkte)

Synonyme: ADAM10 antikoerper, Adam10 antikoerper, adam10 antikoerper, wu:fc03d12 antikoerper, ad10 antikoerper, cd156c antikoerper, kuz antikoerper, kuzbanian antikoerper, madm antikoerper, xadam10 antikoerper, ADAM-10 antikoerper, ADAM 10 antikoerper, AD10 antikoerper, CD156c antikoerper, HsT18717 antikoerper, MADM antikoerper, 1700031C13Rik antikoerper, LOC100219653 antikoerper, zgc:64203 antikoerper, ADAM metallopeptidase domain 10 antikoerper, ADAM metallopeptidase domain 10a antikoerper, ADAM metallopeptidase domain 10 S homeolog antikoerper, a disintegrin and metallopeptidase domain 10 antikoerper, ADAM metallopeptidase domain 10b antikoerper, ADAM10 antikoerper, Adam10 antikoerper, adam10a antikoerper, adam10.S antikoerper, adam10b antikoerper

Hintergrund: ADAM10, A Disintegrin and Metalloproteinase Domain 10, is also know as AD10. ADAM10 is a member of the ADAM family and members of this family are cell surface proteins with a unique structure possessing both potential adhesion and protease function. The ADAM10 gene is mapped to chromosome 15q21.3-q23. ADAM proteins contain an N-terminal signal sequence, followed by a prodomain, a metalloprotease-like domain, a disintegrin-like domain, a cysteine-rich region, an EGF -like repeat, a transmembrane domain, and a C-terminal cytoplasmic tail. Conversion of the membrane-bound precursor to a secreted mature protein is mediated by a protease termed TNFA convertase. ADAM10 possesses TNFA convertase activity.

Synonyms: A disintegrin and metalloprotease domain 10 antibody|A disintegrin and metalloproteinase domain 10 antibody|AD 10 antibody|AD10 antibody|ADA10_HUMAN antibody|ADAM 10 antibody|ADAM metallopeptidase domain 10 antibody|ADAM10 antibody|CD 156c antibody|CD156c antibody|CD156c antigen antibody|CDw156 antibody|disintegrin and metalloproteinase domain containing protein 10 antibody|Disintegrin and metalloproteinase domain-containing protein 10 antibody|HsT 18717 antibody|HsT18717 antibody|Kuz antibody|Kuzbanian antibody|Kuzbanian protein homolog antibody|MADM antibody|Mammalian disintegrin metalloprotease antibody|Mammalian disintegrin-metalloprotease antibody

UniProt: O14672

Pathways: Notch Signalweg, EGFR Signaling Pathway