CYP24A1 Antikörper (AA 153-514)

Produktnummer ABIN3042784

Produktdetails anti-CYP24A1 Antikörper

Target: CYP24A1 (Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 (CYP24A1))

Bindungsspezifität: AA 153-514

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP24A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: cytochrome P450, family 24, subfamily A, polypeptide 1
Protein Name: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human CYP24A1 recombinant protein (Position: E153-R514). Human CYP24A1 shares 86.2% amino acid (aa) sequence identity with both mouse and rat CYP24A1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu CYP24A1

Target: CYP24A1 (Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 (CYP24A1))

Andere Bezeichnung: CYP24A1 (CYP24A1 Produkte)

Synonyme: CP24 antikoerper, CYP24 antikoerper, HCAI antikoerper, P450-CC24 antikoerper, 24-OHase antikoerper, Cyp24 antikoerper, 25-hydroxyvitaminD324-hydroxylase antikoerper, VITD12 antikoerper, CP450CC24 antikoerper, cytochrome P450 family 24 subfamily A member 1 antikoerper, cytochrome P450, family 24, subfamily a, polypeptide 1 antikoerper, cytochrome P450, family 24, subfamily A, polypeptide 1 antikoerper, CYP24A1 antikoerper, Cyp24a1 antikoerper

Hintergrund: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. And this mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms: 1 25 @dihydroxyvitamin D3 24 hydroxylase antibody|1 25 dihydroxyvitamin D(3) 24 hydroxylase antibody|1 antibody|1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial antibody|24 ohase antibody|24-OHase antibody|25-dihydroxyvitamin D(3) 24-hydroxylase antibody|CP 24 antibody|CP24 antibody|CP24A_HUMAN antibody|CYP 24 antibody|CYP24 antibody|CYP24A1 antibody|Cytochrome P450 24A1 antibody| Cytochrome P450 24A1 mitochondrial antibody| cytochrome P450 CC24 antibody|Cytochrome P450 family 24 antibody|Cytochrome P450 family 24 subfamily A polypeptide 1 antibody|Cytochrome P450 subfamily XXIV antibody|Cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase) antibody|Cytochrome P450-CC24 antibody|EC 1.14.13.n4 antibody|Exo mitochondrial protein antibody|HCAI antibody|MGC126273 antibody| MGC126274 antibody|mitochondrial antibody|P450 CC24 antibody|Vitamin D 24 hydroxylase antibody|Vitamin D(3) 24 hydroxylase antibody| Vitamin D(3) 24-hydroxylase antibody

Gen-ID: 1591

UniProt: Q07973

Pathways: Metabolism of Steroid Hormones and Vitamin D