PINX1 Antikörper (N-Term)

Produktnummer ABIN3042502

Produktdetails anti-PINX1 Antikörper

Target: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Bindungsspezifität: AA 54-83, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for PIN2/TERF1-interacting telomerase inhibitor 1(PINX1) detection. Tested with WB in Human.

Sequenz: DHIKVQVKNN HLGLGATINN EDNWIAHQDD

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for PIN2/TERF1-interacting telomerase inhibitor 1(PINX1) detection. Tested with WB in Human.
Gene Name: PIN2/TERF1 interacting, telomerase inhibitor 1
Protein Name: PIN2/TERF1-interacting telomerase inhibitor 1

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human PINX1 (54-83aa DHIKVQVKNNHLGLGATINNEDNWIAHQDD), different from the related mouse and rat sequences by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu PINX1

Target: PINX1 (PIN2/TERF1 Interacting, Telomerase Inhibitor 1 (PINX1))

Andere Bezeichnung: PINX1 (PINX1 Produkte)

Synonyme: PINX1 antikoerper, LPTL antikoerper, LPTS antikoerper, 2210403I16Rik antikoerper, 2610028A01Rik antikoerper, 67-11-3 antikoerper, AU024023 antikoerper, LPTS1 antikoerper, RGD1566025 antikoerper, PIN2/TERF1 interacting telomerase inhibitor 1 antikoerper, PIN2/TERF1 interacting, telomerase inhibitor 1 antikoerper, PINX1 antikoerper, Pinx1 antikoerper

Hintergrund: PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.

Synonyms: 67-11-3 protein antibodyFLJ20565 antibody|Hepatocellular carcinoma-related putative tumor suppressor antibody|Liver-related putative tumor suppressor antibody|LPTL antibody|LPTS antibody|MGC8850 antibody|OTTHUMP00000224984 antibody|OTTHUMP00000224985 antibody| OTTHUMP00000224986 antibody|OTTHUMP00000225053 antibody|OTTHUMP00000225054 antibody|PIN2 interacting protein 1 antibody|Pin2-interacting protein X1 antibody|PIN2/TERF1-interacting telomerase inhibitor 1 antibody|PINX1 antibody|PINX1_HUMAN antibody|Protein 67-11-3 antibody|TRF1-interacting protein 1 antibody

Gen-ID: 54984