PPP3CA Antikörper (C-Term)

Produktnummer ABIN3042493

Produktdetails anti-PPP3CA Antikörper

Target: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Bindungsspezifität: AA 488-521, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP3CA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform(PPP3CA) detection. Tested with WB in Human.

Sequenz: DAMPSDANLN SINKALTSET NGTDSNGSNS SNIQ

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform(PPP3CA) detection. Tested with WB in Human.
Gene Name: protein phosphatase 3, catalytic subunit, alpha isozyme
Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Calcineurin A (488-521aa DAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ), different from the related mouse and rat sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-PPP3CA Antikörper (ABIN3042493)

Chu, Li, Gao, Wang, Han: "Buckwheat Rutin Inhibits AngII-induced Cardiomyocyte Hypertrophy via Blockade of CaN-dependent Signal Pathway." in: Iranian journal of pharmaceutical research : IJPR, Vol. 13, Issue 4, pp. 1347-55, (2015) (PubMed).

Details zu PPP3CA

Target: PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))

Andere Bezeichnung: PPP3CA (PPP3CA Produkte)

Synonyme: CALN antikoerper, CALNA antikoerper, CALNA1 antikoerper, CCN1 antikoerper, CNA1 antikoerper, PPP2B antikoerper, 2900074D19Rik antikoerper, AI841391 antikoerper, AW413465 antikoerper, CN antikoerper, Caln antikoerper, Calna antikoerper, CnA antikoerper, Calna1 antikoerper, calcineurin antikoerper, caln antikoerper, calna antikoerper, calna1 antikoerper, ccn1 antikoerper, cna1 antikoerper, ppp2b antikoerper, fj46e08 antikoerper, si:dkeyp-79c2.2 antikoerper, wu:fj46e08 antikoerper, ppp3ca antikoerper, protein phosphatase 3 catalytic subunit alpha antikoerper, protein phosphatase 3, catalytic subunit, alpha isoform antikoerper, protein phosphatase 3, catalytic subunit, alpha isozyme antikoerper, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) antikoerper, protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog antikoerper, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antikoerper, PPP3CA antikoerper, Ppp3ca antikoerper, ppp3ca antikoerper, ppp3ca.L antikoerper, LOC100205420 antikoerper

Hintergrund: Calcineurin A is also known as PPP3CA. It is mapped to 4q24. Semsarian et al. (1999) and Musaro et al. (1999) independently showed that IGF1stimulates skeletal muscle hypertrophy and a switch to glycolytic metabolism by activating calcineurin A and inducing the nuclear translocation of transcription factor NFATC1. Semsarian et al. (1999) found that hypertrophy was suppressed by the calcineurin inhibitors cyclosporin A or FK506, but not by inhibitors of the MAP kinase or phosphatidylinositol-3-OH kinase pathways. Musaro et al. (1999) showed that expression of a dominant-negative calcineurin mutant also repressed myocyte differentiation and hypertrophy. Musaro et al. (1999) demonstrated that either IGF1 or activated calcineurin induces expression of transcription factor GATA2, which accumulates in a subset of myocyte nuclei, where it associates with calcineurin and a specific dephosphorylated isoform of NFATC1.

Synonyms: Alpha isoform formerly PPP2B antibody|Calcineurin A alpha antibody|Calcineurin A1 antibody|CalcineurinA antibody|Calmodulin dependent calcineurin A subunit alpha isoform antibody|Calmodulin-dependent calcineurin A subunit alpha isoform antibody|CALN antibody|CALNA 1 antibody|CALNA antibody|CALNA1 antibody|CAM PRP catalytic subunit antibody|CAM-PRP catalytic subunit antibody|CCN 1 antibody|CCN1 antibody|CNA 1 antibody|CNA alpha antibody|CNA antibody|CNA1 antibody|FLJ26613 antibody|MGC52248 antibody|PP2BA_HUMAN antibody|PPP2B antibody|PPP3CA antibody|Protein phosphatase 2B catalytic subunit antibody|Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform antibody|Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA antibody|Protein phosphatase 3 catalytic subunit alpha isozyme antibody|Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform antibody|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody

Gen-ID: 5530

UniProt: Q08209

Pathways: RTK Signalweg, WNT Signalweg, Fc-epsilon Rezeptor Signalübertragung, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling