GDNF Antikörper (AA 78-211)

Produktnummer ABIN3042421

Produktdetails anti-GDNF Antikörper

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Bindungsspezifität: AA 78-211

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GDNF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Glial cell line-derived neurotrophic factor(GDNF) detection. Tested with WB in Human,Rat.

Kreuzreaktivität (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Glial cell line-derived neurotrophic factor(GDNF) detection. Tested with WB in Human,Rat.
Gene Name: glial cell derived neurotrophic factor
Protein Name: Glial cell line-derived neurotrophic factor

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human GDNF recombinant protein (Position: S78-I211). Human GDNF shares 93% amino acid (aa) sequence identity with both mouse and rat GDNF.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, The detection limit for GDNF is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-GDNF Antikörper (ABIN3042421)

A, Xu, Zhao, Li, Qi, Li, Wang, Zhou: "Surface functionalization of TiO2 nanotubes with minocycline and its in vitro biological effects on Schwann cells." in: Biomedical engineering online, Vol. 17, Issue 1, pp. 88, (2018) (PubMed).

Zhang, Shi, Li, Zhang, Hao: "Lipopolysaccharide inhibits the self-renewal of spermatogonial stem cells in vitro via downregulation of GDNF expression in Sertoli cells." in: Reproductive toxicology (Elmsford, N.Y.), Vol. 45, pp. 87-93, (2014) (PubMed).

Liu, Wang, Liu, Yang, Xu, Ren: "Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterine growth restriction." in: Neural regeneration research, Vol. 8, Issue 23, pp. 2190-7, (2014) (PubMed).

Li, Xia, Zhang, Wu: "S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk." in: PLoS ONE, Vol. 6, Issue 6, pp. e21663, (2011) (PubMed).

Details zu GDNF

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Andere Bezeichnung: GDNF (GDNF Produkte)

Synonyme: gdnf antikoerper, GDNF antikoerper, AI385739 antikoerper, gdnfa antikoerper, hfb1-gdnf antikoerper, ATF1 antikoerper, ATF2 antikoerper, HFB1-GDNF antikoerper, HSCR3 antikoerper, glial cell derived neurotrophic factor antikoerper, glial cell derived neurotrophic factor a antikoerper, glial cell line derived neurotrophic factor antikoerper, glial cell derived neurotrophic factor L homeolog antikoerper, Gdnf antikoerper, gdnfa antikoerper, GDNF antikoerper, gdnf.L antikoerper

Hintergrund: Glial cell line-derived neurotrophic factor(GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. GDNF is also a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures. In addition to its potential role in the differentiation and survival of central nervous system neurons, it has profound effects on kidney organogenesis and the development of the peripheral nervous system. GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.

Synonyms: gdnf antibody|GDNF_HUMAN antibody|Glial cell derived neurotrophic factor antibody|Glial Cell Line Derived Neurotrophic Factor antibody|Glial cell line-derived neurotrophic factor antibody|Glial derived neurotrophic factor antibody|HFB1 GDNF antibody|hGDNF antibody|HSCR3 antibody

Gen-ID: 2668

UniProt: P39905

Pathways: RTK Signalweg, Synaptic Membrane, Tube Formation, Autophagie, Smooth Muscle Cell Migration