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HMGN1 Antikörper (pSer20, pSer24)

HMGN1 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Affe, Huhn, Frosch WB, IF, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN303233
  • Target Alle HMGN1 Antikörper anzeigen
    HMGN1 (High Mobility Group Nucleosome Binding Domain 1 (HMGN1))
    Bindungsspezifität
    • 18
    • 15
    • 15
    • 14
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 19-28, pSer20, pSer24
    Reaktivität
    • 67
    • 17
    • 13
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Schwein, Hund, Affe, Huhn, Frosch
    Wirt
    • 69
    • 1
    Kaninchen
    Klonalität
    • 69
    • 1
    Polyklonal
    Konjugat
    • 32
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser HMGN1 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 29
    • 28
    • 28
    • 26
    • 13
    • 10
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Aufreinigung
    Immunoaffinity Chromatography.
    Immunogen
    Synthetic peptide corresponding to Amino acids 19-28 of human HMGN protein containing pSer20 and pSer24.
    Top Product
    Discover our top product HMGN1 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry on Paraffin Sections (20 μg/mL). Immunofluorescence. Western Blot(1/500-1/2000). ELISA (1/5000-1/25000).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody undiluted (in aliquots) at-20 °C. Dilute only prior to immediate use.
  • Target
    HMGN1 (High Mobility Group Nucleosome Binding Domain 1 (HMGN1))
    Andere Bezeichnung
    HMGN1 (HMGN1 Produkte)
    Synonyme
    HMG14 antikoerper, hmg14 antikoerper, hmgn1 antikoerper, hmgn1b antikoerper, HMG-14 antikoerper, Hmg14 antikoerper, high mobility group nucleosome binding domain 1 antikoerper, high mobility group nucleosome binding domain 1 S homeolog antikoerper, high mobility group nucleosomal binding domain 1 antikoerper, non-histone chromosomal protein HMG-14 antikoerper, HMGN1 antikoerper, hmgn1.S antikoerper, hmgn1 antikoerper, Hmgn1 antikoerper, LOC785479 antikoerper
    Hintergrund
    HMGNs are proteins that bind chromatin effectively reducing the compaction of the chromatin fiber and enhancing access to DNA regulatory sequences. Members of this family have a conserved chromatin binding domain which is phosphorylated during mitosis. The sequence immunized is conserved in several species. As such, this reagent is designed as a universal reagent for the detection of all phosphorylated HMGN proteins. The High Mobility Group (HMG) proteins were originally isolated from mammalian cells and were named according to their electrophoretic mobility in polyacrylamide gels. HMGs were arbitrarily classed as a specific type of nonhistone proteins based on the observation that they are ubiquitous to mammalian cells, that they share certain physical properties, and that they are associated with isolated chromatin. HMG proteins and are now subdivided into 3 families: the HMGB (formerly HMG-1/-2) family, the HMGN (formerly HMG-14/-17) family, and the HMGA (formerly HMG-I/Y/C) family. Each HMG family has a characteristic functional sequence motif. The functional motif of the HMGB family is called the "HMG-box," that of the HMGN family, the "nucleosomal binding domain," and that of the HMGA family, the "AT-hook." The functional motifs characteristic of these canonical HMGs are widespread among nuclear proteins in a variety of organisms. Proteins containing any of these functional motifs embedded in their sequence are known as "HMG motif proteins."Synonyms: HMG-14, HMG14, High mobility group nucleosome-binding domain-containing protein 1, Non-histone chromosomal protein HMG-14
    Gen-ID
    3150
    NCBI Accession
    NP_004956
    UniProt
    P05114
    Pathways
    Chromatin Binding
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