MRP1 Antikörper

Produktnummer ABIN3031671

Produktdetails anti-MRP1 Antikörper

Target: MRP1 (Macrophage Inflammatory Protein Related Protein 1 (MRP1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MRP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Amino acids LLQQRGLFYSMAKDAGLV (human) were used as the immunogen for this MRP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the MRP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the MRP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu MRP1

Target: MRP1 (Macrophage Inflammatory Protein Related Protein 1 (MRP1))

Andere Bezeichnung: MRP1 (MRP1 Produkte)

Synonyme: Abcc1a antikoerper, Avcc1a antikoerper, Mrp antikoerper, Mrp1 antikoerper, BTCC-1 antikoerper, DRAP-27 antikoerper, MIC3 antikoerper, MRP-1 antikoerper, TSPAN-29 antikoerper, TSPAN29 antikoerper, Scya6 antikoerper, c10 antikoerper, ATP binding cassette subfamily C member 1 antikoerper, CD9 molecule antikoerper, chemokine (C-C motif) ligand 6 antikoerper, Abcc1 antikoerper, CD9 antikoerper, Ccl6 antikoerper

Hintergrund: ABCC1 (ATP-binding cassette, subfamily C, member 1), also called MRP1, is a protein that in humans is encoded by the ABCC1 gene. ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. It is a plasma membrane drug-efflux pump.The gene is mapped to chromosome 16p13.1 by isotopic in situ hybridization. ABCC1/MRP1 functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates and it also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Blocking MRP1 efflux pumps increases the susceptibility of the cells to the toxic effects of unconjugated bilirubin, suggesting that it is an important protector in this scenario. The protein clears beta-amyloid from brains of mice and can be activated by thiethylperazine. And Chemotaxis assays show that MPR1-mediated transport of S1P influenced mast-cell migration, but not mast-cell degranulation.

UniProt: P33527

Pathways: Response to Water Deprivation, Cell-Cell Junction Organization