IL4 Receptor Antikörper (Middle Region)

Produktnummer ABIN3031482

Produktdetails anti-IL4 Receptor Antikörper

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL4 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human IL4R (TKWHNSYREPFEQH) was used as the immunogen for this IL4R antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the IL4R antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the IL4R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu IL4 Receptor

Target: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Andere Bezeichnung: IL4R (IL4R Produkte)

Synonyme: IL4R antikoerper, il-4ra antikoerper, zgc:113063 antikoerper, CD124 antikoerper, IL-4RA antikoerper, IL4RA antikoerper, Il4ra antikoerper, IL4 antikoerper, Il4r antikoerper, interleukin 4 receptor antikoerper, interleukin 4 receptor, tandem duplicate 1 antikoerper, interleukin 4 receptor, alpha antikoerper, IL4R antikoerper, il4r.1 antikoerper, Il4r antikoerper, Il4ra antikoerper

Hintergrund: IL4R (Interleukin 4 receptor) is a human gene that encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. The gene is localized to 16p12.1-p11.2 by in situ hybridization and Southern blot analysis of DNA from a panel of mouse-human somatic cell lines. IL4 plays a major role in immunoglobulin E(IgE) production. Its signal is conferred to effector cells through binding to the alpha chain of the IL4 receptor. IL4 interacts with IL4R with high affinity, leading to dimerization with either the common gamma chain,a component of receptors for a number of cytokines, to create a type I receptor, or with IL13RA1 to form a type II receptor. The IL4R gene contains 12 exons and the protein is a complex of at least two components, one of which is a novel affinity converting subunit that is critical for cellular signal transduction.

UniProt: P24394

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process