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HDAC8 Antikörper (N-Term)

HDAC8 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3031236
  • Target Alle HDAC8 Antikörper anzeigen
    HDAC8 (Histone Deacetylase 8 (HDAC8))
    Bindungsspezifität
    • 24
    • 15
    • 11
    • 10
    • 9
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 99
    • 52
    • 35
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 94
    • 5
    • 1
    Kaninchen
    Klonalität
    • 85
    • 15
    Polyklonal
    Konjugat
    • 44
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser HDAC8 Antikörper ist unkonjugiert
    Applikation
    • 49
    • 40
    • 32
    • 27
    • 26
    • 17
    • 12
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Antigen affinity
    Immunogen
    An amino acid sequence from the N-terminus of human HDAC8 (YIYSPEYVSMCDSLAK) was used as the immunogen for this HDAC8 antibody.
    Isotyp
    IgG
    Top Product
    Discover our top product HDAC8 Primärantikörper
  • Applikationshinweise
    The stated application concentrations are suggested starting amounts. Titration of the HDAC8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Lagerung
    -20 °C
    Informationen zur Lagerung
    After reconstitution, the HDAC8 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    HDAC8 (Histone Deacetylase 8 (HDAC8))
    Andere Bezeichnung
    HDAC8 (HDAC8 Produkte)
    Synonyme
    HD8 antikoerper, CDLS5 antikoerper, HDACL1 antikoerper, MRXS6 antikoerper, RPD3 antikoerper, WTS antikoerper, 2610007D20Rik antikoerper, RGD1562895 antikoerper, wu:fd19a02 antikoerper, zgc:66196 antikoerper, ATHDA8 antikoerper, HDA8 antikoerper, HISTONE DEACETYLASE 8 antikoerper, T27G7.14 antikoerper, T27G7_14 antikoerper, histone deacetylase 8 antikoerper, histone deacetylase 8 antikoerper, histone deacetylase 8 L homeolog antikoerper, CC1G_05302 antikoerper, hdac8 antikoerper, HDAC8 antikoerper, Hdac8 antikoerper, hdac8.L antikoerper, HDA08 antikoerper
    Hintergrund
    Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene, and is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Sequence analysis predicted that the 377-amino acid HDAC8 protein contains the 9 conserved HDAC blocks that are presumably important for catalytic function. HDAC8 shares 54 % sequence similarity with HDAC1 and HDAC2 and 39 % similarity with HDAC3, making it a class I HDAC. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
    UniProt
    Q9BY41
    Pathways
    Cellular Glucan Metabolic Process
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