GRIN1/NMDAR1 Antikörper (N-Term)

Produktnummer ABIN3031070

Produktdetails anti-GRIN1/NMDAR1 Antikörper

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN1/NMDAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human NMDAR1 (RKHEQMFREAVNQANKRH) was used as the immunogen for this NMDAR1 antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the NMDAR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the NMDAR1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu GRIN1/NMDAR1

Target: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Andere Bezeichnung: NMDAR1 (GRIN1 Produkte)

Synonyme: GluN1 antikoerper, MRD8 antikoerper, NMDA1 antikoerper, NMDAR1 antikoerper, NR1 antikoerper, nmda1 antikoerper, nmdar1 antikoerper, GB19253 antikoerper, GRIN1 antikoerper, NMD-R1 antikoerper, Z16 antikoerper, GluRdelta1 antikoerper, GluRzeta1 antikoerper, M100174 antikoerper, Nmdar antikoerper, Rgsc174 antikoerper, NMDAR1.1 antikoerper, zgc:152678 antikoerper, glutamate ionotropic receptor NMDA type subunit 1 antikoerper, glutamate receptor, ionotropic, N-methyl D-aspartate 1 S homeolog antikoerper, NMDA receptor 1 antikoerper, G protein-regulated inducer of neurite outgrowth 1 antikoerper, glutamate receptor, ionotropic, NMDA1 (zeta 1) antikoerper, glutamate receptor, ionotropic, N-methyl D-aspartate 1a antikoerper, GRIN1 antikoerper, grin1.S antikoerper, grin1 antikoerper, Grin1 antikoerper, Nmdar1 antikoerper, Gprin1 antikoerper, grin1a antikoerper

Hintergrund: The NMDA receptor(NMDAR) is a specific type of ionotropic glutamate receptor. NMDA(N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. NMDAR1 gene is mapped to 9q34.3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties. It consists of 21 exons distributed over about 31 kb. Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence. The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped'. The gene is a candidate for the site of the mutation in torsion dystonia.The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell. NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, such as excitotoxicity.

UniProt: Q05586

Pathways: Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity