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CRTC2 Antikörper (C-Term)

CRTC2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3030573
  • Target Alle CRTC2 Antikörper anzeigen
    CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
    Bindungsspezifität
    • 16
    • 8
    • 8
    • 8
    • 7
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 67
    • 22
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 59
    • 6
    • 4
    • 1
    Kaninchen
    Klonalität
    • 63
    • 7
    Polyklonal
    Konjugat
    • 30
    • 7
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CRTC2 Antikörper ist unkonjugiert
    Applikation
    • 62
    • 43
    • 19
    • 17
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    Antigen affinity
    Immunogen
    An amino acid sequence from the C-terminus of human CRTC2 (QDPHTFNHQNLTHCSRH) was used as the immunogen for this CRTC2 antibody.
    Isotyp
    IgG
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  • Applikationshinweise
    The stated application concentrations are suggested starting amounts. Titration of the CRTC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Lagerung
    -20 °C
    Informationen zur Lagerung
    After reconstitution, the CRTC2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))
    Andere Bezeichnung
    CRTC2 (CRTC2 Produkte)
    Synonyme
    CRTC2 antikoerper, TORC-2 antikoerper, TORC2 antikoerper, 4632407F12Rik antikoerper, Torc2 antikoerper, mTORC2 antikoerper, RGD1308903 antikoerper, CREB regulated transcription coactivator 2 antikoerper, CRTC2 antikoerper, Crtc2 antikoerper
    Hintergrund
    CREB-Regulated Transcription Coactivator 2, also known as TORC2, is a protein that in humans is encoded by the CRTC2 gene. The International Radiation Hybrid Mapping Consortium mapped the gene to chromosome 1. By cotransfection of TORC2 and reporter genes in HeLa cells, Iourgenko et al.(2003) found that it potently activated expression of genes driven by the IL8 promoter or a promoter carrying multiple CRE-like sequences. Liu et al.(2008) demonstrated that a fasting-inducible switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin-1(SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1. Using mice and primary mouse hepatocytes, Wang et al.(2009) found that the protein functioned as a dual sensor for endoplasmic reticulum(ER) stress and fasting signals.
    UniProt
    Q53ET0
    Pathways
    AMPK Signaling, Carbohydrate Homeostasis
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