BAG3 Antikörper (C-Term)

Produktnummer ABIN3030138

Produktdetails anti-BAG3 Antikörper

Target: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAG3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human BAG family molecular chaperone regulator 3 (LEKLEQKAIDVPGQVQ) was used as the immunogen for this Bag3 antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the BAG3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the BAG3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu BAG3

Target: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Andere Bezeichnung: BAG3 (BAG3 Produkte)

Synonyme: bag3-A antikoerper, MGC53113 antikoerper, zgc:100859 antikoerper, BAG3 antikoerper, ATBAG3 antikoerper, BCL-2-associated athanogene 3 antikoerper, T28J14.160 antikoerper, T28J14_160 antikoerper, BAG-3 antikoerper, BIS antikoerper, CAIR-1 antikoerper, MFM6 antikoerper, AA407278 antikoerper, Bis antikoerper, mg638 antikoerper, BCL2 associated athanogene 3 L homeolog antikoerper, BCL2-associated athanogene 3 antikoerper, BCL2 associated athanogene 3 antikoerper, BCL-2-associated athanogene 3 antikoerper, Bcl2-associated athanogene 3 antikoerper, bag3.L antikoerper, bag3 antikoerper, BAG3 antikoerper, Bag3 antikoerper

Hintergrund: BAG family molecular chaperone regulator 3 is a member of a conserved family of cyto-protective proteins that bind to and regulate Hsp70 family molecular chaperones. BAG3 mutations are responsible for familial dilated cardiomyopathy. Polymorphisms are also associated with sporadic forms of the disease together with HSPB7 locus. In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity in flies, mice and men.

UniProt: O95817