ANGPTL3 Antikörper (N-Term)

Produktnummer ABIN3029952

Produktdetails anti-ANGPTL3 Antikörper

Target: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANGPTL3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human Angiopoietin-Like 3 (EPKSRFAMLDDVKILAN) was used as the immunogen for this ANGPTL3 antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the ANGPTL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the ANGPTL3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu ANGPTL3

Target: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Andere Bezeichnung: ANGPTL3 (ANGPTL3 Produkte)

Synonyme: fb60e11 antikoerper, fb66h02 antikoerper, wu:fb60e11 antikoerper, wu:fb66h02 antikoerper, zgc:111943 antikoerper, ANGPTL3 antikoerper, LOC100230785 antikoerper, ANG-5 antikoerper, ANGPT5 antikoerper, ANL3 antikoerper, FHBL2 antikoerper, hypl antikoerper, angiopoietin-like 3 antikoerper, angiopoietin like 3 antikoerper, angptl3 antikoerper, ANGPTL3 antikoerper, Angptl3 antikoerper

Hintergrund: Angiopoietin-Like 3, also known as ANGPT5, is a protein which in humans is encoded by the ANGPTL3 gene. The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. By radiation hybrid mapping and the use of surrounding genes, Conklin et al.(1999) mapped the gene to chromosome 1p31. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen(FBN)-like domain. Angptl3 also acts as dual inhibitor of lipoprotein lipase(LPL) and endothelial lipase(EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels.

UniProt: Q9Y5C1