TLR10 Antikörper (N-Term)

Produktnummer ABIN3029161

Produktdetails anti-TLR10 Antikörper

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human Toll-like receptor 10 (DLKTFEFNKELRYLD) was used as the immunogen for this TLR10 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the TLR10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the TLR10 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu TLR10

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Andere Bezeichnung: TLR10 (TLR10 Produkte)

Synonyme: TLR10 antikoerper, CD290 antikoerper, toll like receptor 10 antikoerper, toll-like receptor 10 antikoerper, TLR10 antikoerper, Tlr10 antikoerper

Hintergrund: Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. By genomic sequence analysis, Hasan et al.(2005) determined that the gene is clustered with TLR1 and TLR6 on chromosome 4p14. By coimmunoprecipitation analysis, Hasan et al.(2005) found that TLR10 associated with itself and with TLR1 and TLR2, but not with MD2. Signaling studies showed that TLR10 required MYD88, but not TIRAP, TRAM(TICAM2), or TRIF (TICAM1), to activate immune system promoters. Pro674 within the TLR10 TIR domain was required to activate all promoter examined.

UniProt: Q9BXR5

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades