SOCS3 Antikörper (Middle Region)

Produktnummer ABIN3029044

Produktdetails anti-SOCS3 Antikörper

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human SOCS3 (RDSSDQRHFFTLSVK) was used as the immunogen for this SOCS3 antibody (100% mouse homology).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the SOCS3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the SOCS3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Andere Bezeichnung: SOCS3 (SOCS3 Produkte)

Synonyme: socs3 antikoerper, fj09e12 antikoerper, zgc:56537 antikoerper, wu:fj09e12 antikoerper, MGC64393 antikoerper, MGC75749 antikoerper, xsocs3 antikoerper, MGC81248 antikoerper, atod4 antikoerper, cis3 antikoerper, cish3 antikoerper, socs-3 antikoerper, ssi-3 antikoerper, ssi3 antikoerper, SOCS3 antikoerper, ATOD4 antikoerper, CIS3 antikoerper, Cish3 antikoerper, SOCS-3 antikoerper, SSI-3 antikoerper, SSI3 antikoerper, Cis3 antikoerper, EF-10 antikoerper, Ef10 antikoerper, Ssi3 antikoerper, Socs-3 antikoerper, Ssi-3 antikoerper, suppressor of cytokine signaling 3a antikoerper, suppressor of cytokine signaling 3 S homeolog antikoerper, suppressor of cytokine signaling 3 antikoerper, suppressor of cytokine signaling 3 L homeolog antikoerper, socs3a antikoerper, socs3.S antikoerper, socs3 antikoerper, socs3.L antikoerper, SOCS3 antikoerper, Socs3 antikoerper

Hintergrund: Suppressor of cytokine signaling 3 is a protein that in humans is encoded by the SOCS3 gene. It is transiently expressed by multiple cell lineages within the immune system and functions predominantly as a negative regulator of cytokines that activate the JAK-STAT3 pathway. This gene encodes a member of the STAT-induced STAT inhibitor(SSI), also known as suppressor of cytokine signaling(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon(IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.

UniProt: O14543

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus, Hepatitis C