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MUC5AC Antikörper

MUC5AC Reaktivität: Human, Maus, Ratte, Affe, Cat, Kaninchen, Huhn, Schwein, Hedgehog IF, FACS, IHC (p) Wirt: Maus Monoclonal 45M1 unconjugated
Produktnummer ABIN3026774
  • Target Alle MUC5AC Antikörper anzeigen
    MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))
    Reaktivität
    • 89
    • 54
    • 39
    • 19
    • 18
    • 17
    • 15
    • 14
    • 13
    • 6
    • 1
    • 1
    Human, Maus, Ratte, Affe, Cat, Kaninchen, Huhn, Schwein, Hedgehog
    Wirt
    • 59
    • 57
    • 1
    Maus
    Klonalität
    • 60
    • 57
    Monoklonal
    Konjugat
    • 61
    • 16
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MUC5AC Antikörper ist unkonjugiert
    Applikation
    • 54
    • 41
    • 31
    • 30
    • 29
    • 20
    • 18
    • 17
    • 15
    • 13
    • 13
    • 12
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Keine Kreuzreaktivität
    Rind (Kuh)
    Produktmerkmale
    This antibody recognizes the peptide core of gastric mucin M1 (>1,000 kDa), now identified as Mucin-5AC or MUC5AC. The MUC5AC epitope is destroyed by beta-mercaptoethanol and proteases but not by periodate treatment. MUC5AC antibody reacts with the gastric epithelium of normal human gastrointestinal tract as well as with the precancerous and cancerous colon but not with normal adult colon. It also reacts with fetal colonic mucosa. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to re-expression of the peptide core of gastric (or fetal colonic) mucins.
    Aufreinigung
    Protein G affinity chromatography
    Immunogen
    M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient was used as the immunogen for this MUC5AC antibody.
    Klon
    45M1
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product MUC5AC Primärantikörper
  • Applikationshinweise
    The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the MUC5AC antibody to be titered up or down for optimal performance.

    1. Staining of formalin-fixed tissues requires boiling tissue sections in 10  mM citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. FACS: 0.5-1 μg/million cells,IF: 1-2 μg/mL,IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1),Prediluted format : incubate for 30 min at RT (2)

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.2 mg/mL
    Buffer
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store the MUC5AC antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))
    Andere Bezeichnung
    MUC5AC Mucin-5AC (MUC5AC Produkte)
    Synonyme
    MUC5 antikoerper, TBM antikoerper, leB antikoerper, 2210005L13Rik antikoerper, MGM antikoerper, mucin 5AC, oligomeric mucus/gel-forming antikoerper, putative gastric mucin antikoerper, mucin 5, subtypes A and C, tracheobronchial/gastric antikoerper, mucin 2, oligomeric mucus/gel-forming antikoerper, MUC5AC antikoerper, Smp_144070 antikoerper, Muc5ac antikoerper, MUC2 antikoerper
    Hintergrund
    This antibody recognizes the peptide core of gastric mucin M1 (>1,000  kDa), now identified as Mucin-5AC or MUC5AC. The MUC5AC epitope is destroyed by beta-mercaptoethanol and proteases but not by periodate treatment. MUC5AC antibody reacts with the gastric epithelium of normal human gastrointestinal tract as well as with the precancerous and cancerous colon but not with normal adult colon. It also reacts with fetal colonic mucosa. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to re-expression of the peptide core of gastric (or fetal colonic) mucins.
    Gen-ID
    4586
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