CLECSF9 antikoerper, MINCLE antikoerper, C86253 antikoerper, Clecsf9 antikoerper, Mincle antikoerper, CLEC4E antikoerper, C-type lectin domain family 4 member E antikoerper, C-type lectin domain family 4, member e antikoerper, C-type lectin domain family 4, member E antikoerper, CLEC4E antikoerper, Clec4e antikoerper, LOC611538 antikoerper
Hintergrund
CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130 kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRgamma, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.