Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

Presenilin 1 Antikörper (AA 1-160)

PSEN1 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3023160
  • Target Alle Presenilin 1 (PSEN1) Antikörper anzeigen
    Presenilin 1 (PSEN1)
    Bindungsspezifität
    • 31
    • 15
    • 15
    • 13
    • 11
    • 11
    • 8
    • 7
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-160
    Reaktivität
    • 125
    • 101
    • 66
    • 9
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 113
    • 36
    • 2
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 147
    • 8
    Polyklonal
    Konjugat
    • 50
    • 12
    • 12
    • 9
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser Presenilin 1 Antikörper ist unkonjugiert
    Applikation
    • 122
    • 56
    • 55
    • 52
    • 52
    • 18
    • 15
    • 13
    • 11
    • 7
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Sequenz
    MTELPAPLSY FQNAQMSEDN HLSNTNDNRE RQEHNDRRSL GHPEPLSNGR PQGNSRQVVE QDEEEDEELT LKYGAKHVIM LFVPVTLCMV VVVATIKSVS FYTRKDGQLI YTPFTEDTET VGQRALHSIL NAAIMISVIV VMTILLVVLY KYRCYKVIHA
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Presenilin 1 (NP_015557.2).
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze / thaw cycles
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Presenilin 1 (PSEN1)
    Andere Bezeichnung
    PSEN1 (PSEN1 Produkte)
    Synonyme
    pre1 antikoerper, psen antikoerper, zfPS1 antikoerper, zf-PS1 antikoerper, ad3 antikoerper, fad antikoerper, ps1 antikoerper, s182 antikoerper, X-PS-beta antikoerper, X-PS-alpha antikoerper, AD3 antikoerper, FAD antikoerper, PS-1 antikoerper, PS1 antikoerper, S182 antikoerper, Ad3h antikoerper, presenilin 1 antikoerper, presenilin 1 L homeolog antikoerper, psen1 antikoerper, PSEN1 antikoerper, Psen1 antikoerper, psen1.L antikoerper
    Hintergrund
    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.,AD3,FAD,PS-1,PS1,S182,Presenilin 1,PSEN1,Cancer,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Notch Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Neurodegenerative Diseases Markers,PSEN1
    Molekulargewicht
    21 kDa/42 kDa/46 kDa/48 kDa/52 kDa
    Gen-ID
    5663
    UniProt
    P49768
    Pathways
    Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
Sie sind hier:
Kundenservice