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HDAC3 Antikörper (AA 299-428)

HDAC3 Reaktivität: Human WB, IHC, IF, IP, ChIP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3023018
  • Target Alle HDAC3 Antikörper anzeigen
    HDAC3 (Histone Deacetylase 3 (HDAC3))
    Bindungsspezifität
    • 23
    • 20
    • 16
    • 10
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 299-428
    Reaktivität
    • 116
    • 67
    • 64
    • 9
    • 7
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 88
    • 27
    • 1
    Kaninchen
    Klonalität
    • 88
    • 28
    Polyklonal
    Konjugat
    • 67
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser HDAC3 Antikörper ist unkonjugiert
    Applikation
    • 101
    • 53
    • 39
    • 28
    • 27
    • 26
    • 16
    • 16
    • 14
    • 9
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP)
    Sequenz
    TVRNVARCWT YETSLLVEEA ISEELPYSEY FEYFAPDFTL HPDVSTRIEN QNSRQYLDQI RQTIFENLKM LNHAPSVQIH DVPADLLTYD RTDEADAEER GPEENYSRPE APNEFYDGDH DNDKESDVEI
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 299-428 of human HDAC3 (NP_003874.2).
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200,IP,1:50 - 1:200,ChIP,1:20 - 1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze / thaw cycles
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Fan, Li, Wang, Emerson, Xu: "A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer." in: Cancers, Vol. 13, Issue 15, (2021) (PubMed).

    Wei, Liu, Chen, Gao, Lu, Zhang, Ding, Wang, Chen, Shi, Li, Yu, Wong: "Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription." in: Cell research, Vol. 27, Issue 7, pp. 898-915, (2018) (PubMed).

    Liu, Lu, Zhang, Zhang, Lu, Xie, Cheng, Shen, Zhang: "C/EBPα negatively regulates SIRT7 expression via recruiting HDAC3 to the upstream-promoter of hepatocellular carcinoma cells." in: Biochimica et biophysica acta, Vol. 1859, Issue 2, pp. 348-54, (2016) (PubMed).

  • Target
    HDAC3 (Histone Deacetylase 3 (HDAC3))
    Andere Bezeichnung
    HDAC3 (HDAC3 Produkte)
    Synonyme
    CG2128 antikoerper, DHDAC3 antikoerper, DmHDAC3 antikoerper, Dmel\\CG2128 antikoerper, Dromel_CG2128_FBtr0078767_hdac3_mORF antikoerper, HDAC antikoerper, HDAC3 antikoerper, Hdac 3 antikoerper, dHDAC3 antikoerper, dmHDA402 antikoerper, hdac3 antikoerper, HDm antikoerper, hd3 antikoerper, RPD3 antikoerper, XRpd3 antikoerper, rpd3-2 antikoerper, HD3 antikoerper, RPD3-2 antikoerper, AW537363 antikoerper, zgc:55927 antikoerper, Histone deacetylase 3 antikoerper, histone deacetylase 3 antikoerper, histone deacetylase 3 S homeolog antikoerper, HDAC3 antikoerper, hdac3 antikoerper, CNL05260 antikoerper, Hdac3 antikoerper, hdac3.S antikoerper
    Hintergrund
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.,HD3,RPD3,RPD3-2,HDAC3,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cancer,Tumor suppressors,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,G1/S Checkpoint,Notch Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Endocrine & Metabolism,Lipid Metabolism,Immunology & Inflammation,NF-kB Signaling Pathway,Stem Cells,Cardiovascular,Heart,Hypertrophy,Lipids,HDAC3
    Molekulargewicht
    48 kDa/49 kDa
    Gen-ID
    8841
    UniProt
    O15379
    Pathways
    Neurotrophin Signalübertragung, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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