Cathepsin K Antikörper (AA 115-329)

Produktnummer ABIN3022539

Produktdetails anti-Cathepsin K Antikörper

Target: Cathepsin K (CTSK)

Bindungsspezifität: AA 115-329

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin K Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: APDSVDYRKK GYVTPVKNQG QCGSCWAFSS VGALEGQLKK KTGKLLNLSP QNLVDCVSEN DGCGGGYMTN AFQYVQKNRG IDSEDAYPYV GQEESCMYNP TGKAAKCRGY REIPEGNEKA LKRAVARVGP VSVAIDASLT SFQFYSKGVY YDESCNSDNL NHAVLAVGYG IQKGNKHWII KNSWGENWGN KGYILMARNK NNACGIANLA SFPKM

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 115-329 of human CTSK (NP_000387.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-Cathepsin K Antikörper (ABIN3022539)

Doss, Samarpita, Ganesan, Rasool: "Ferulic acid, a dietary polyphenol suppresses osteoclast differentiation and bone erosion via the inhibition of RANKL dependent NF-κB signalling pathway." in: Life sciences, Vol. 207, pp. 284-295, (2018) (PubMed).

Details zu Cathepsin K

Target: Cathepsin K (CTSK)

Andere Bezeichnung: CTSK (CTSK Produkte)

Synonyme: CTS02 antikoerper, CTSO antikoerper, CTSO1 antikoerper, CTSO2 antikoerper, PKND antikoerper, PYCD antikoerper, AI323530 antikoerper, MMS10-Q antikoerper, Ms10q antikoerper, catK antikoerper, CTSK antikoerper, wu:fa95f03 antikoerper, wu:fb08b05 antikoerper, zgc:110367 antikoerper, cts02 antikoerper, ctso antikoerper, ctso1 antikoerper, ctso2 antikoerper, pknd antikoerper, pycd antikoerper, OC-2 antikoerper, catk antikoerper, cathepsin K antikoerper, cathepsin K L homeolog antikoerper, Cathepsin K antikoerper, CTSK antikoerper, Ctsk antikoerper, ctsk antikoerper, ctsk.L antikoerper, catk antikoerper

Hintergrund: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.,CTSK,CTS02,CTSO,CTSO1,CTSO2,PKND,PYCD,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Extracellular Matrix,Ubiquitin,Neuroscience,Cardiovascular,Angiogenesis,CTSK

Molekulargewicht: 36 kDa

Gen-ID: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades