AKR1C3 Antikörper (AA 1-323)

Produktnummer ABIN3022536

Produktdetails anti-AKR1C3 Antikörper

Target: AKR1C3 (Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))

Bindungsspezifität: AA 1-323

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKR1C3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Sequenz: MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD RNLHYFNSDS FASHPNYPYS DEY

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C3 (NP_003730.4).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu AKR1C3

Target: AKR1C3 (Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))

Andere Bezeichnung: AKR1C3 (AKR1C3 Produkte)

Synonyme: AKR1C3 antikoerper, PGFS antikoerper, MGC134333 antikoerper, DD3 antikoerper, DDX antikoerper, HA1753 antikoerper, HAKRB antikoerper, HAKRe antikoerper, HSD17B5 antikoerper, hluPGFS antikoerper, Akr1c18 antikoerper, aldo-keto reductase family 1, member C3 L homeolog antikoerper, aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) antikoerper, aldo-keto reductase family 1 member C2 antikoerper, aldo-keto reductase family 1 member C3 antikoerper, aldo-keto reductase family 1, member C3 antikoerper, akr1c3.L antikoerper, AKR1C3 antikoerper, LOC722496 antikoerper, Akr1c3 antikoerper

Hintergrund: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.,AKR1C3,DD3,DDX,HA1753,HAKRB,HAKRe,HSD17B5,PGFS,hluPGFS,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Neuroscience,AKR1C3

Molekulargewicht: 23 kDa/36 kDa

Gen-ID: 8644

UniProt: P42330

Pathways: Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Biosynthesis, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, C21-Steroid Hormone Metabolic Process, Protein targeting to Nucleus