CDC42 Antikörper (AA 25-191)

Produktnummer ABIN3021671

Produktdetails anti-CDC42 Antikörper

Target: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Bindungsspezifität: AA 25-191

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC42 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequenz: TNKFPSEYVP TVFDNYAVTV MIGGEPYTLG LFDTAGQEDY DRLRPLSYPQ TDVFLVCFSV VSPSSFENVK EKWVPEITHH CPKTPFLLVG TQIDLRDDPS TIEKLAKNKQ KPITPETAEK LARDLKAVKY VECSALTQKG LKNVFDEAIL AALEPPEPKK SRRCVLL

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-191 of human CDC42 (NP_001782.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-CDC42 Antikörper (ABIN3021671)

Liu, Feng, Chen, Luo, Yan, Chen, Lin, Ding, Wen: "Dcf1 Triggers Dendritic Spine Formation and Facilitates Memory Acquisition." in: Molecular neurobiology, Vol. 55, Issue 1, pp. 763-775, (2018) (PubMed).

Fang, Li, Han, Zhao, Gao, Yan, Luo: "Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats." in: Biochemical and biophysical research communications, Vol. 490, Issue 3, pp. 719-725, (2017) (PubMed).

Details zu CDC42

Target: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Andere Bezeichnung: CDC42 (CDC42 Produkte)

Synonyme: CDC42Hs antikoerper, G25K antikoerper, AI747189 antikoerper, AU018915 antikoerper, cdc42a antikoerper, wu:fb07d08 antikoerper, wu:fj62g06 antikoerper, zgc:63918 antikoerper, Xcdc42 antikoerper, cdc42hs antikoerper, g25k antikoerper, CDC42 antikoerper, CG12530 antikoerper, Cdc42Dm antikoerper, D-CDC42 antikoerper, D-Cdc42 antikoerper, D-cdc42 antikoerper, DCDC42 antikoerper, DCdc42 antikoerper, Dcdc42 antikoerper, Dm Cdc42 antikoerper, DmCDC42 antikoerper, Dmcdc42 antikoerper, Dmel\\CG12530 antikoerper, cdc42 antikoerper, cell division cycle 42 antikoerper, Cell division control protein 42 homolog antikoerper, cell division control protein 42 homolog antikoerper, cell division cycle 42 L homeolog antikoerper, CG12530 gene product from transcript CG12530-RC antikoerper, Rho family GTPase antikoerper, CDC42 antikoerper, Cdc42 antikoerper, cdc42 antikoerper, LOC100636735 antikoerper, LOC100637699 antikoerper, LOC100638834 antikoerper, cdc42.L antikoerper

Hintergrund: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.,CDC42,CDC42Hs,G25K,TKS,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,G protein signaling,Signal Transduction,Kinase,ErbB-HER Signaling Pathway,MAPK-JNK Signaling Pathway,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cell Adhesion,Cytoskeleton,Microtubules,Actins,TGF-b-Smad Signaling Pathway,Immunology & Inflammation,Cytokines,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,CDC42

Molekulargewicht: 21 kDa

Gen-ID: 998

UniProt: P60953

Pathways: MAPK Signalweg, Microtubule Dynamics, RTK Signalweg, WNT Signalweg, T-Zell Rezeptor Signalweg, EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2, EGFR Downregulation, VEGF Signaling