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VHL Antikörper (AA 1-172)
VHL
Reaktivität: Human
WB, IHC, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN3020968
Produktdetails anti-VHL Antikörper
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Target
Alle VHL Antikörper anzeigen
VHL
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Bindungsspezifität
Alle Epitope für VHL Antikörper
AA 1-172
Reaktivität
Alle Reaktivitäten für VHL Antikörper
Human
Wirt
Alle Wirte für VHL Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für VHL Antikörper
Polyklonal
Konjugat
Alle Konjugate für VHL Antikörper
Dieser VHL Antikörper ist unkonjugiert
Applikation
Alle Applikationen für VHL Antikörper
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Sequenz
MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRVYTLKER CLQVVRSLVK PENYRRLDIV RSLYEDLEDH PNVQKDLERL TQERIAHQRM GD
Kreuzreaktivität
Human, Maus, Ratte
Produktmerkmale
Polyclonal Antibodies
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human VHL (NP_937799.1).
Isotyp
IgG
Top Product
Discover our top product VHL Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
(ausblenden)
Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid freeze / thaw cycles
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C. Avoid freeze / thaw cycles.
Referenzen für anti-VHL Antikörper (ABIN3020968)
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Liu, Cai, Hu, Mei, Zhang, Ouyang, Wang, Zhang, Xiao : "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL). " in: The Journal of biological chemistry , Vol. 291 , Issue 49 , pp. 25692-25705 , (2017 ) (PubMed ).
Du, Zhang, Zhang, Ouyang, Wang, Liu, Li, Ji, Liu, Xiao : "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 195 , Issue 4 , pp. 1782-90 , (2015 ) (PubMed ).
Wang, Zhang, Ji, Liu, Ouyang, Xiao : "The von hippel-lindau protein suppresses androgen receptor activity. " in: Molecular endocrinology (Baltimore, Md.) , Vol. 28 , Issue 2 , pp. 239-48 , (2015 ) (PubMed ).
Details zu VHL
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Target
VHL
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Andere Bezeichnung
VHL (VHL Produkte )
Synonyme
HRCA1 antikoerper, RCA1 antikoerper, VHL1 antikoerper, pVHL antikoerper, BcDNA:RH61560 antikoerper, CG13221 antikoerper, DVhl antikoerper, Dmel\\CG13221 antikoerper, Dvhl antikoerper, VHL antikoerper, d-VHL antikoerper, d-vhl antikoerper, dVHL antikoerper, dmVHL antikoerper, vhl antikoerper, rca1 antikoerper, vhl1 antikoerper, hrca1 antikoerper, zgc:158722 antikoerper, Vhlh antikoerper, von Hippel-Lindau tumor suppressor antikoerper, von Hippel-Lindau antikoerper, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase antikoerper, von Hippel-Lindau disease tumor suppressor antikoerper, VHL antikoerper, Vhl antikoerper, vhl antikoerper, CpipJ_CPIJ009992 antikoerper
Hintergrund
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.,VHL,HRCA1,RCA1,VHL1,pVHL,PVHL,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell cycle inhibitors,Cell differentiation,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,Cardiovascular,Angiogenesis,VHL
Molekulargewicht
18 kDa/19 kDa/24 kDa
Gen-ID
7428
UniProt
P40337
Pathways
Tube Formation , Signaling Events mediated by VEGFR1 and VEGFR2 , Ubiquitin Proteasome Pathway
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