ARAP1 Antikörper (AA 1190-1450)

Produktnummer ABIN302078

Produktdetails anti-ARAP1 Antikörper

Target: ARAP1 (ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1))

Bindungsspezifität: AA 1190-1450

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ARAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Spezifität: The antibody ARAP1-2 reacts with C-terminal part of ARAP1 (intracellular epitope), a 160 kDa adaptor protein.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1

Klon: ARAP1-2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blotting: Recommended dilution: 2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-ARAP1 Antikörper (ABIN302078)

Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).

Details zu ARAP1

Target: ARAP1 (ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1))

Andere Bezeichnung: ARAP1 (ARAP1 Produkte)

Synonyme: CENTD2 antikoerper, ARAP1 antikoerper, Ci-ArfGAP-8 antikoerper, 2410002L19Rik antikoerper, Centd2 antikoerper, mKIAA0782 antikoerper, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 antikoerper, centaurin, delta 2 antikoerper, ARAP1 antikoerper, centd2 antikoerper, Arap1 antikoerper

Hintergrund: ArfGAP with RhoGAP domain, ankyrin repeat and PH d,ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.,CED2, CENTD2

Gen-ID: 116985

UniProt: Q96P48