Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

PDPK1 Antikörper (pSer241)

PDPK1 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3020427
  • Target Alle PDPK1 Antikörper anzeigen
    PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))
    Bindungsspezifität
    • 26
    • 19
    • 16
    • 15
    • 15
    • 15
    • 9
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer241
    Reaktivität
    • 185
    • 120
    • 84
    • 11
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 180
    • 21
    • 1
    Kaninchen
    Klonalität
    • 167
    • 35
    Polyklonal
    Konjugat
    • 90
    • 12
    • 10
    • 9
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    Dieser PDPK1 Antikörper ist unkonjugiert
    Applikation
    • 155
    • 70
    • 53
    • 53
    • 27
    • 27
    • 12
    • 11
    • 10
    • 8
    • 8
    • 8
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Phosphorylated Antibodies
    Immunogen
    A phospho specific peptide corresponding to residues surrounding S241 of human PDK1/PDPK1
    Isotyp
    IgG
    Top Product
    Discover our top product PDPK1 Primärantikörper
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:100 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Zhang, Yu, Chu, Wang, Xiong, Cai, Liu, Gao, Tao, Li, Li, Liang, Yang: "Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis." in: Molecular cell, Vol. 71, Issue 2, pp. 201-215.e7, (2018) (PubMed).

  • Target
    PDPK1 (3-phosphoinositide Dependent Protein Kinase-1 (PDPK1))
    Andere Bezeichnung
    PDPK1 (PDPK1 Produkte)
    Synonyme
    pdpk1 antikoerper, MGC82080 antikoerper, PDK1 antikoerper, PDPK2 antikoerper, PRO0461 antikoerper, Pdk1 antikoerper, zgc:153787 antikoerper, 3'-phosphoinositide-dependent protein kinase 1 antikoerper, 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 antikoerper, ATPDK1 antikoerper, AtPDK1 antikoerper, T32M21.110 antikoerper, T32M21_110 antikoerper, zgc:77318 antikoerper, 3-phosphoinositide dependent protein kinase 1 antikoerper, 3-phosphoinositide dependent protein kinase 1 L homeolog antikoerper, 3-phosphoinositide dependent protein kinase-1 antikoerper, 3-phosphoinositide dependent protein kinase 1a antikoerper, 3-phosphoinositide-dependent protein kinase 1 antikoerper, 3'-phosphoinositide-dependent protein kinase 1 antikoerper, 3-phosphoinositide dependent protein kinase 1b antikoerper, PDPK1 antikoerper, pdpk1.L antikoerper, pdpk1 antikoerper, Pdpk1 antikoerper, pdpk1a antikoerper, LOC100380750 antikoerper, pdk-1 antikoerper, PDK1 antikoerper, pdpk1b antikoerper
    Hintergrund
    Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling . Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive.,PDPK1,PDK1,PDPK2,PDPK2P,PRO0461,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,G protein signaling,Kinase,Serine/threonine kinases,PI3K-Akt Signaling Pathway,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Cytoskeleton,Microfilaments,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Immunology & Inflammation,T Cell Receptor Signaling Pathway,NF-kB Signaling Pathway,Neuroscience,Protein phosphorylation,PDPK1
    Molekulargewicht
    48 kDa/50 kDa/58 kDa/60 kDa/63 kDa
    Gen-ID
    5170
    UniProt
    O15530
    Pathways
    PI3K-Akt Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
Kundenservice