ATG4C Antikörper (N-Term) (PE)
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- Target Alle ATG4C Antikörper anzeigen
- ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ATG4C Antikörper ist konjugiert mit PE
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- Predicted molecular weight at ~52.5 kDa. Observed molecular weights at ~45-60 kDa.
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Peptide Affinity Purified
- Immunogen
- Synthetic peptide from the N-terminal of human ATG4C
- Top Product
- Discover our top product ATG4C Primärantikörper
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- Applikationshinweise
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- WB (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- Kommentare
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A 1:1000 dilution of ABIN2868970 was sufficient for detection of ATG4C on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Conjugated antibodies should be stored at 4°C
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- Target
- ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))
- Andere Bezeichnung
- ATG4C (ATG4C Produkte)
- Synonyme
- apg4c antikoerper, atg4cl antikoerper, zgc:86888 antikoerper, wu:fc56g07 antikoerper, APG4-C antikoerper, APG4C antikoerper, AUTL1 antikoerper, AUTL3 antikoerper, Apg4-C antikoerper, Apg4c antikoerper, Atg4cl antikoerper, Autl1 antikoerper, autophagy related 4C cysteine peptidase antikoerper, autophagy related 4C, cysteine peptidase antikoerper, cysteine protease ATG4C antikoerper, ATG4C antikoerper, atg4c antikoerper, Tsp_15996 antikoerper, Atg4c antikoerper
- Hintergrund
- ATG4C belongs to the peptidase C54 family. It is a cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. It also has an activity of delipidating enzyme for the PE-conjugated forms (1).
- Gen-ID
- 84938
- NCBI Accession
- NP_116241
- UniProt
- Q96DT6
- Pathways
- Autophagie
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