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ATG4C Antikörper (N-Term) (PE)

ATG4C Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal PE
Produktnummer ABIN2868970
  • Target Alle ATG4C Antikörper anzeigen
    ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))
    Bindungsspezifität
    • 15
    • 15
    • 11
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 66
    • 30
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 59
    • 11
    • 2
    • 1
    Kaninchen
    Klonalität
    • 63
    • 10
    Polyklonal
    Konjugat
    • 31
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ATG4C Antikörper ist konjugiert mit PE
    Applikation
    • 67
    • 28
    • 23
    • 23
    • 13
    • 13
    • 13
    • 10
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Predicted molecular weight at ~52.5 kDa. Observed molecular weights at ~45-60 kDa.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Peptide Affinity Purified
    Immunogen
    Synthetic peptide from the N-terminal of human ATG4C
    Top Product
    Discover our top product ATG4C Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    A 1:1000 dilution of ABIN2868970 was sufficient for detection of ATG4C on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))
    Andere Bezeichnung
    ATG4C (ATG4C Produkte)
    Synonyme
    apg4c antikoerper, atg4cl antikoerper, zgc:86888 antikoerper, wu:fc56g07 antikoerper, APG4-C antikoerper, APG4C antikoerper, AUTL1 antikoerper, AUTL3 antikoerper, Apg4-C antikoerper, Apg4c antikoerper, Atg4cl antikoerper, Autl1 antikoerper, autophagy related 4C cysteine peptidase antikoerper, autophagy related 4C, cysteine peptidase antikoerper, cysteine protease ATG4C antikoerper, ATG4C antikoerper, atg4c antikoerper, Tsp_15996 antikoerper, Atg4c antikoerper
    Hintergrund
    ATG4C belongs to the peptidase C54 family. It is a cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. It also has an activity of delipidating enzyme for the PE-conjugated forms (1).
    Gen-ID
    84938
    NCBI Accession
    NP_116241
    UniProt
    Q96DT6
    Pathways
    Autophagie
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