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Bcl-2 Antikörper (N-Term)

BCL2 Reaktivität: Human WB, IF, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2857047
  • Target Alle Bcl-2 (BCL2) Antikörper anzeigen
    Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
    Bindungsspezifität
    • 54
    • 37
    • 23
    • 22
    • 21
    • 18
    • 17
    • 16
    • 16
    • 16
    • 15
    • 13
    • 13
    • 10
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 453
    • 190
    • 187
    • 38
    • 34
    • 22
    • 22
    • 19
    • 17
    • 16
    • 12
    • 5
    • 5
    • 1
    • 1
    • 1
    Human
    Wirt
    • 357
    • 124
    • 6
    • 2
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 353
    • 138
    Polyklonal
    Konjugat
    • 217
    • 35
    • 34
    • 25
    • 25
    • 15
    • 14
    • 13
    • 11
    • 11
    • 11
    • 11
    • 9
    • 9
    • 9
    • 9
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Bcl-2 Antikörper ist unkonjugiert
    Applikation
    • 395
    • 201
    • 168
    • 123
    • 107
    • 102
    • 92
    • 75
    • 63
    • 32
    • 29
    • 25
    • 18
    • 8
    • 8
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Kreuzreaktivität
    Cat, Hund, Human, Maus, Ratte, Zebrafisch (Danio rerio)
    Produktmerkmale
    Rabbit Polyclonal antibody to BCL2 (B-cell CLL/lymphoma 2)
    Bcl-2 antibody [N1N2], N-term
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Bcl-2. The exact sequence is proprietary.
    Isotyp
    IgG
  • Applikationshinweise
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: BCL2-transfected 293T

    Validation: Comparison, Orthogonal, Overexpression

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.2 mg/mL
    Buffer
    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Tvrdá, Ďuračka, Benko, Kováčik, Lovíšek, Gálová, Žiarovská, Schwarzová, Kačániová: "Ejaculatory Abstinence Affects the Sperm Quality in Normozoospermic Men-How Does the Seminal Bacteriome Respond?" in: International journal of molecular sciences, Vol. 24, Issue 4, (2023) (PubMed).

    Lin, Lecca, Yang, Luo, Scerba, Tweedie, Huang, Jung, Kim, Yang, Hoffer, Wang, Greig: "3,6'-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation." in: eLife, Vol. 9, (2020) (PubMed).

    Luo, Huang, Yuan, Yang, Wang, Huang, Tang, Sun: "Abdominal paracentesis drainage attenuates severe acute pancreatitis by enhancing cell apoptosis via PI3K/AKT signaling pathway." in: Apoptosis : an international journal on programmed cell death, Vol. 25, Issue 3-4, pp. 290-303, (2020) (PubMed).

    Yang, Tang, Xu, Liu, Tan, Gao, Sun, Ding, Liu, Chen: "PI3K/mTORC1/2 inhibitor PQR309 inhibits proliferation and induces apoptosis in human glioblastoma cells." in: Oncology reports, Vol. 43, Issue 3, pp. 773-782, (2020) (PubMed).

    Wen, Sun, Tan, Liu, Huang, Chen, Qi, Tang: "Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress." in: World journal of gastroenterology, Vol. 26, Issue 1, pp. 35-54, (2020) (PubMed).

    Wu, Luo, Liu, Cui, Guo, Zhao, Guo, Bai, Guo, Feng, Qu et al.: "Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4-CHOP apoptosis pathways in diabetic mice via Smad3 signalling ..." in: Cell proliferation, Vol. 53, Issue 2, pp. e12759, (2020) (PubMed).

    Jiao, Li, Shao, Zhang, Gong, Yang, Wang, Tan, Sun, Xuan, Yu, Li, Gao, Liu, Xu, Li, Zhang, Zhang: "lncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca2+ overload in myocardial infarction mice model." in: Cell death & disease, Vol. 10, Issue 12, pp. 942, (2020) (PubMed).

    Lam, Liang, Jiang, Peng: "Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice." in: Biomolecules, Vol. 10, Issue 7, (2020) (PubMed).

    Wen, Liu, Lin, Luo, Tang, Huang, Sun, Tang: "NADPH Oxidase Hyperactivity Contributes to Cardiac Dysfunction and Apoptosis in Rats with Severe Experimental Pancreatitis through ROS-Mediated MAPK Signaling Pathway." in: Oxidative medicine and cellular longevity, Vol. 2019, pp. 4578175, (2019) (PubMed).

    Batsaikhan, Wang, Scerba, Tweedie, Greig, Miller, Hoffer, Lin, Wang: "Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6'-Dithiothalidomide on Traumatic Brain Injury." in: International journal of molecular sciences, Vol. 20, Issue 3, (2019) (PubMed).

    Xiao, Zeng, Guan, Wang, Wang, Shi, Shou, Deng, Xin: "FKBP12.6 protects heart from AngII-induced hypertrophy through inhibiting Ca2+ /calmodulin-mediated signalling pathways in vivo and in vitro." in: Journal of cellular and molecular medicine, Vol. 22, Issue 7, pp. 3638-3651, (2019) (PubMed).

    Li, Luo, Dong, Liu, Wu, Zhang, Hu, Zhang, Song, Li: "Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 107, (2018) (PubMed).

    Wang, Hsieh, Liu, Lin, Wu, Chen, Fang: "Reactive oxygen species-driven mitochondrial injury induces apoptosis by teroxirone in human non-small cell lung cancer cells." in: Oncology letters, Vol. 14, Issue 3, pp. 3503-3509, (2017) (PubMed).

  • Target
    Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
    Andere Bezeichnung
    BCL2 apoptosis regulator (BCL2 Produkte)
    Synonyme
    Bcl-2 antikoerper, PPP1R50 antikoerper, bcl-2 antikoerper, AW986256 antikoerper, C430015F12Rik antikoerper, D630044D05Rik antikoerper, D830018M01Rik antikoerper, BCL-2 antikoerper, Bcl2 antikoerper, BCL2, apoptosis regulator antikoerper, B cell leukemia/lymphoma 2 antikoerper, B-cell CLL/lymphoma 2a antikoerper, B-cell CLL/lymphoma 2 protein antikoerper, BCL2 antikoerper, Bcl2 antikoerper, bcl2a antikoerper, BCL-2 antikoerper
    Hintergrund
    This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

    Cellular Localization: Mitochondrion outer membrane , Nucleus membrane , Endoplasmic reticulum membrane
    Molekulargewicht
    26 kDa
    Gen-ID
    596
    UniProt
    P10415
    Pathways
    MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
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