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BRE Antikörper

KO Validated BRE Reaktivität: Human WB, IF, ICC, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2856093
  • Target Alle BRE Antikörper anzeigen
    BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
    Reaktivität
    • 26
    • 24
    • 22
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 39
    • 2
    Kaninchen
    Klonalität
    • 41
    Polyklonal
    Konjugat
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BRE Antikörper ist unkonjugiert
    Applikation
    • 30
    • 13
    • 13
    • 12
    • 9
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Rabbit Polyclonal antibody to BRCC45 (brain and reproductive organ-expressed (TNFRSF1A modulator))
    BRCC45 antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Güteklasse
    KO Validated
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human BRCC45. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product BRE Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: 293T , A431 , C8D30 , rat testis , HeLa

    Validation: KO/KD

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
    Andere Bezeichnung
    BRISC and BRCA1 A complex member 2 (BRE Produkte)
    Synonyme
    brcc4 antikoerper, brcc45 antikoerper, BRE antikoerper, LOC100231620 antikoerper, BRCC4 antikoerper, BRCC45 antikoerper, 6030405P19Rik antikoerper, AI429776 antikoerper, B830038C02Rik antikoerper, im:7141046 antikoerper, zgc:110368 antikoerper, BRISC and BRCA1 A complex member 2 antikoerper, brain and reproductive organ-expressed (TNFRSF1A modulator) antikoerper, BRISC and BRCA1 A complex member 2 L homeolog antikoerper, babam2 antikoerper, BABAM2 antikoerper, Babam2 antikoerper, BRE antikoerper, babam2.L antikoerper
    Hintergrund
    Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between MERIT40/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.

    Cellular Localization: Cytoplasm , Nucleus
    Molekulargewicht
    44 kDa
    Gen-ID
    9577
    UniProt
    Q9NXR7
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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