PPP1CA Antikörper (Center)

Produktnummer ABIN2856071

Produktdetails anti-PPP1CA Antikörper

Target: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Bindungsspezifität: Center

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP1CA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Kreuzreaktivität: Rind (Kuh), Maus

Kreuzreaktivität (Details): Mouse (100 %), Bovine (100 %)

Produktmerkmale: Rabbit Polyclonal antibody to PPP1A (protein phosphatase 1, catalytic subunit, alpha isozyme)
PPP1A antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human PPP1A. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Kommentare:

Positive Control: 293T , A431 , rat brain

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.58 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-PPP1CA Antikörper (ABIN2856071)

Wei, Ngo, Wu, Lee: "Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint." in: Molecular biology of the cell, Vol. 22, Issue 19, pp. 3584-94, (2012) (PubMed).

Details zu PPP1CA

Target: PPP1CA (Protein Phosphatase 1, Catalytic Subunit, alpha Isoform (PPP1CA))

Andere Bezeichnung: PPP1A (PPP1CA Produkte)

Synonyme: PP-1A antikoerper, PP1A antikoerper, PP1alpha antikoerper, PPP1A antikoerper, Ppp1c antikoerper, dism2 antikoerper, ppp1a antikoerper, wu:fc04c08 antikoerper, wu:fc09b07 antikoerper, wu:fc30g11 antikoerper, wu:fe05h08 antikoerper, zgc:85729 antikoerper, Ppp1ca antikoerper, fb18b03 antikoerper, fd20h04 antikoerper, wu:fb18b03 antikoerper, wu:fd20h04 antikoerper, wu:fl22a03 antikoerper, zgc:55744 antikoerper, zgc:76940 antikoerper, protein phosphatase 1 catalytic subunit alpha antikoerper, protein phosphatase 1, catalytic subunit, alpha isoform antikoerper, protein phosphatase 1, catalytic subunit, alpha isozyme L homeolog antikoerper, protein phosphatase 1, catalytic subunit, alpha isozyme antikoerper, protein phosphatase 1, catalytic subunit, alpha isozyme a antikoerper, protein phosphatase 1, catalytic subunit, alpha isozyme b antikoerper, PPP1CA antikoerper, Ppp1ca antikoerper, ppp1ca.L antikoerper, ppp1ca antikoerper, ppp1caa antikoerper, ppp1cab antikoerper

Hintergrund: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Cytoplasm

Molekulargewicht: 38 kDa

Gen-ID: 5499

Pathways: M Phase, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Lipid Metabolism