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HLA-DPA1 Antikörper

HLA-DPA1 Reaktivität: Human WB, IHC (p), IF, ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855822
  • Target Alle HLA-DPA1 Antikörper anzeigen
    HLA-DPA1 (Major Histocompatibility Complex, Class II, DP alpha 1 (HLA-DPA1))
    Reaktivität
    • 37
    • 1
    • 1
    Human
    Wirt
    • 34
    • 3
    Kaninchen
    Klonalität
    • 35
    • 2
    Polyklonal
    Konjugat
    • 14
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HLA-DPA1 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 22
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    Rabbit Polyclonal antibody to HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)
    HLA-DPA1 antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human HLA-DPA1. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product HLA-DPA1 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    HLA-DPA1 (Major Histocompatibility Complex, Class II, DP alpha 1 (HLA-DPA1))
    Andere Bezeichnung
    major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1 Produkte)
    Synonyme
    DP(W3) antikoerper, DP(W4) antikoerper, HLA-DP1A antikoerper, HLADP antikoerper, HLASB antikoerper, PLT1 antikoerper, major histocompatibility complex, class II, DP alpha 1 antikoerper, HLA-DPA1 antikoerper
    Hintergrund
    HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

    Cellular Localization: Membrane, Single-pass type I membrane protein
    Molekulargewicht
    29 kDa
    Gen-ID
    3113
    UniProt
    P20036
    Pathways
    T-Zell Rezeptor Signalweg, Cancer Immune Checkpoints
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