PLK1 Antikörper
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- Target Alle PLK1 Antikörper anzeigen
- PLK1 (Polo-Like Kinase 1 (PLK1))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PLK1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Kreuzreaktivität
- Human, Maus
- Produktmerkmale
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Rabbit Polyclonal antibody to PLK1 (polo-like kinase 1)
PLK1 antibody [N2C2], Internal - Aufreinigung
- Purified by antigen-affinity chromatography.
- Güteklasse
- KO Validated
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human PLK1. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product PLK1 Primärantikörper
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- Applikationshinweise
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Kommentare
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Validation: KO/KD
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- PLK1 (Polo-Like Kinase 1 (PLK1))
- Andere Bezeichnung
- polo like kinase 1 (PLK1 Produkte)
- Synonyme
- PLK antikoerper, STPK13 antikoerper, plk antikoerper, PLK-1 antikoerper, Plx1 antikoerper, stpk13 antikoerper, Plk antikoerper, cb525 antikoerper, cb636 antikoerper, ik:tdsubc_2d1 antikoerper, wu:fb37g11 antikoerper, wu:fb76g03 antikoerper, xx:tdsubc_2d1 antikoerper, polo like kinase 1 antikoerper, polo like kinase 1 S homeolog antikoerper, polo-like kinase 1 antikoerper, polo-like kinase 1 (Drosophila) antikoerper, Serine/threonine-protein kinase plk-1 antikoerper, PLK1 antikoerper, plk1.S antikoerper, plk1 antikoerper, Plk1 antikoerper, plk-1 antikoerper
- Hintergrund
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Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.
Cellular Localization: Nucleus. This antibody also stains PLK1 on spindles, kinetochores, and midbodies. - Molekulargewicht
- 68 kDa
- Gen-ID
- 5347
- UniProt
- P53350
- Pathways
- Zellzyklus, M Phase
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