Kallikrein 7 Antikörper

Produktnummer ABIN2855653

Produktdetails anti-Kallikrein 7 Antikörper

Target: Kallikrein 7 (KLK7)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kallikrein 7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to KLK7 (kallikrein-related peptidase 7)
KLK7 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Kallikrein 7. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:10000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Kallikrein 7-transfected 293T

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.69 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-Kallikrein 7 Antikörper (ABIN2855653)

Delaunay, Deschamps, Haddada, Walker, Soosaipillai, Soualmia, El Amri, Diamandis, Brattsand, Magdolen, Darmoul: "Aberrant expression of kallikrein-related peptidase 7 is correlated with human melanoma aggressiveness by stimulating cell migration and invasion." in: Molecular oncology, Vol. 11, Issue 10, pp. 1330-1347, (2018) (PubMed).

Details zu Kallikrein 7

Target: Kallikrein 7 (KLK7)

Andere Bezeichnung: kallikrein related peptidase 7 (KLK7 Produkte)

Synonyme: Prss6 antikoerper, SCCE antikoerper, PRSS6 antikoerper, hK7 antikoerper, kallikrein related-peptidase 7 (chymotryptic, stratum corneum) antikoerper, kallikrein-related peptidase 7 antikoerper, kallikrein related peptidase 7 antikoerper, Klk7 antikoerper, KLK7 antikoerper

Hintergrund: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded enzyme is thought to be involved in the proteolysis of intercellular cohesive structures preceding desquamation, which is the shedding of the outermost layer of the epidermis. Alternative splicing of this gene results in two transcript variants encoding the same protein.

Cellular Localization: Secreted

Molekulargewicht: 28 kDa

Gen-ID: 5650

UniProt: P49862

Pathways: Komplementsystem