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BIN1 Antikörper

BIN1 Reaktivität: Human WB, IHC, IF, ICC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855595
  • Target Alle BIN1 Antikörper anzeigen
    BIN1 (Bridging Integrator 1 (BIN1))
    Reaktivität
    • 47
    • 24
    • 19
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 33
    • 13
    • 1
    Kaninchen
    Klonalität
    • 34
    • 13
    Polyklonal
    Konjugat
    • 33
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BIN1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 22
    • 19
    • 9
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    Rabbit Polyclonal antibody to BIN1 (bridging integrator 1)
    BIN1 antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human BIN1. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product BIN1 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Validation: Comparison

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    2.35 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Chan Wah Hak, Khan, Di Meglio, Law, Lucken-Ardjomande Häsler, Quintaneiro, Ferreira, Krause, McMahon, Boucrot: "FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis." in: Nature cell biology, Vol. 20, Issue 9, pp. 1023-1031, (2019) (PubMed).

  • Target
    BIN1 (Bridging Integrator 1 (BIN1))
    Andere Bezeichnung
    bridging integrator 1 (BIN1 Produkte)
    Synonyme
    bin1 antikoerper, MGC53185 antikoerper, amph2 antikoerper, amphl antikoerper, sh3p9 antikoerper, MGC76187 antikoerper, cb57 antikoerper, zgc:86701 antikoerper, BIN1 antikoerper, AMPH2 antikoerper, AMPHL antikoerper, SH3P9 antikoerper, ALP-1 antikoerper, Amphl antikoerper, BRAMP-2 antikoerper, bridging integrator 1 antikoerper, bridging integrator 1 S homeolog antikoerper, bridging integrator 1b antikoerper, BIN1 antikoerper, bin1.S antikoerper, bin1 antikoerper, bin1b antikoerper, Bin1 antikoerper
    Hintergrund
    This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

    Cellular Localization: Isoform BIN1: Nucleus , Isoform IIA: Cytoplasm
    Molekulargewicht
    65 kDa
    Gen-ID
    274
    UniProt
    O00499
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