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Cyclin A Antikörper

KO Validated CCNA2 Reaktivität: Human WB, IF, IHC (p), IP, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2855543
  • Target Alle Cyclin A (CCNA2) Antikörper anzeigen
    Cyclin A (CCNA2) (Cyclin A2 (CCNA2))
    Reaktivität
    • 91
    • 56
    • 33
    • 28
    • 14
    • 14
    • 12
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 58
    • 37
    • 1
    Kaninchen
    Klonalität
    • 49
    • 47
    Polyklonal
    Konjugat
    • 69
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Cyclin A Antikörper ist unkonjugiert
    Applikation
    • 59
    • 30
    • 21
    • 20
    • 18
    • 17
    • 16
    • 9
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Spezifität
    IP/MS validation was supported by references (PMID:30377384)
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Rabbit Polyclonal antibody to Cyclin A2 (cyclin A2)
    Cyclin A2 antibody
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Güteklasse
    KO Validated
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human Cyclin A2. The exact sequence is proprietary.
    Isotyp
    IgG
  • Applikationshinweise
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Kommentare

    Positive Control: Neuro2A , PC-12 , IMR32 , SK-N-AS , HeLa(100 μg/ml Bleomycin treatment for 24 hr)

    Validation: IP/MS, KO/KD, Orthogonal, Overexpression

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.73 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Honda, Inui: "PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression." in: Scientific reports, Vol. 10, Issue 1, pp. 1140, (2020) (PubMed).

    Ogawa, Yaginuma, Nakatomi, Nakajima, Tada-Shigeyama, Addison, Urata, Matsubara, Watanabe, Matsuo, Sato, Honda, Hikiji, Watanabe, Kokabu: "Transducin-like enhancer of split 3 regulates proliferation of melanoma cells via histone deacetylase activity." in: Oncotarget, Vol. 10, Issue 3, pp. 404-414, (2019) (PubMed).

    Fu, Xu, Chen, Li, Zhao, Chen: "Microarray analysis reveals Tmub1 as a cell cycle-associated protein in rat hepatocytes." in: Molecular medicine reports, Vol. 17, Issue 3, pp. 4337-4344, (2018) (PubMed).

    Li, Wu, Lee, Li, Hsieh, Ho, Ho, Chen, Wang, Yen, Yang, Chen: "Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells." in: PLoS ONE, Vol. 9, Issue 8, pp. e104203, (2015) (PubMed).

    Lin, Chou, Lee, Chen, Fong, Chang, Huang, Wu, Chang, Wang, Chiu: "The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB." in: Cancer cell international, Vol. 14, Issue 1, pp. 1, (2014) (PubMed).

  • Target
    Cyclin A (CCNA2) (Cyclin A2 (CCNA2))
    Andere Bezeichnung
    cyclin A2 (CCNA2 Produkte)
    Synonyme
    CCN1 antikoerper, CCNA antikoerper, AA408589 antikoerper, Ccn-1 antikoerper, Ccn1 antikoerper, Ccna antikoerper, CycA2 antikoerper, Cyca antikoerper, cb671 antikoerper, chunp6924 antikoerper, wu:fi36f03 antikoerper, CYCA antikoerper, Cyclin-A2 antikoerper, ccna2 antikoerper, ccn1 antikoerper, ccna antikoerper, ccna1 antikoerper, Cyclin-A antikoerper, cyclinA antikoerper, cyclin A2 antikoerper, cyclin A2 S homeolog antikoerper, cyclin A2 L homeolog antikoerper, CCNA2 antikoerper, Ccna2 antikoerper, ccna2 antikoerper, ccna2.S antikoerper, ccna2.L antikoerper
    Hintergrund
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.

    Cellular Localization: Nucleus , Cytoplasm
    Molekulargewicht
    49 kDa
    Gen-ID
    890
    UniProt
    P20248
    Pathways
    PI3K-Akt Signalweg, Zellzyklus, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
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