Survivin Antikörper

Produktnummer ABIN2854750

Produktdetails anti-Survivin Antikörper

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Survivin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to Survivin (baculoviral IAP repeat containing 5)
Survivin antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Survivin. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: 293T , NIH-3T3

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu Survivin

Target: Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))

Andere Bezeichnung: baculoviral IAP repeat containing 5 (BIRC5 Produkte)

Synonyme: AP14 antikoerper, API4 antikoerper, EPR-1 antikoerper, AAC-11 antikoerper, Api4 antikoerper, TIAP antikoerper, survivin40 antikoerper, bir5a antikoerper, survivin antikoerper, BIR1 antikoerper, Su2 antikoerper, XBIR1 antikoerper, XSurvivin1 antikoerper, Xsvv1 antikoerper, api4 antikoerper, bir1-A antikoerper, epr-1 antikoerper, svv1 antikoerper, xSurvivin antikoerper, xsurv antikoerper, Su1 antikoerper, birc5.2 antikoerper, svv2 antikoerper, xSurvivin2 antikoerper, bir5b antikoerper, SIX antikoerper, birc5.2-a antikoerper, birc5.2-b antikoerper, baculoviral IAP repeat containing 5 antikoerper, baculoviral IAP repeat-containing 5 antikoerper, baculoviral IAP repeat containing 5a antikoerper, baculoviral IAP repeat-containing 5, gene 1 L homeolog antikoerper, baculoviral IAP repeat containing 5 L homeolog antikoerper, baculoviral IAP repeat containing 5b antikoerper, baculoviral IAP repeat containing 5 S homeolog antikoerper, BIRC5 antikoerper, Birc5 antikoerper, birc5a antikoerper, birc5.1.L antikoerper, birc5.2.L antikoerper, birc5b antikoerper, birc5.2.S antikoerper

Hintergrund: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.

Cellular Localization: Cytoplasm , Nucleus , Centromere

Molekulargewicht: 16 kDa

Gen-ID: 332

UniProt: O15392

Pathways: Apoptose, Zellzyklus, Nuclear Hormone Receptor Binding