Mesothelin Antikörper (MSLN) (PE)

Details for Product anti-MSLN Antibody No. ABIN2853589, Anbieter: Anmelden zum Anzeigen
Antigen
  • MPF
  • SMRP
  • 6330420K13Rik
  • CMKRL2
  • Ceprl
  • FEG-1
  • GPCR-Br
  • Gper
  • Gpr30
  • MSLN
  • mesothelin
  • G protein-coupled estrogen receptor 1
  • MSLN
  • Gper1
  • Msln
  • LOC611363
  • LOC100524016
Reaktivität
Maus
171
34
6
3
2
2
2
2
1
1
1
1
Wirt
Ratte
108
50
25
15
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser Mesothelin Antikörper ist konjugiert mit PE
12
10
8
4
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
119
74
43
40
40
13
6
5
5
4
3
3
2
2
2
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen Murine hemangioblast-like cell lineLO
Klon 295D
Isotyp IgG2a
Spezifität This antibody reacts with Mesothelin.
Kreuzreaktivität (Details) Species reactivity (tested):Mouse (LO). Does not work with human (Jurkat).
Reinigung Protein G agarose
Andere Bezeichnung Mesothelin (MSLN Antibody Abstract)
Hintergrund Mesothelin (MSLN) is a GPI-linked cell surface glycoprotein expressed in the mesothelial lining of the body cavities and in mullerian duct epithelium related cancer cells (ovarian, pancreatic cancer, mesothelioma). Both human and mouse mesothelin bind to ovarian cancer antigen CA125/MUC16 with high affinity, mediating cell attachment in vitro, suggesting that mesothelin may facilitate ovarian cancer metastasis.Synonyms: CAK1 antigen, MPF, MSLN, Pre-pro-megakaryocyte-potentiating factor
Gen-ID 56047
NCBI Accession NP_061345
UniProt Q61468
Pathways EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer PBS, 0.09 % Sodium Azide, 1 % BSA
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Mesothelin (MSLN) antibody (PE) (ABIN2853589) anti-Mesothelin (MSLN) antibody (PE)
Allgemeine Veröffentlichungen Ho, Hassan, Zhang, Wang, Onda, Bera, Pastan: "Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 10, pp. 3814-20, 2005 (PubMed).

Rump, Morikawa, Tanaka, Minami, Umesaki, Takeuchi, Miyajima: "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion." in: The Journal of biological chemistry, Vol. 279, Issue 10, pp. 9190-8, 2004 (PubMed).

Nakayama, Hara, Hibi, Hirano, Miyajima: "A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth." in: The Journal of biological chemistry, Vol. 274, Issue 35, pp. 24766-72, 1999 (PubMed).

Kojima, Oh-eda, Hattori, Taniguchi, Tamura, Ochi, Yamaguchi: "Molecular cloning and expression of megakaryocyte potentiating factor cDNA." in: The Journal of biological chemistry, Vol. 270, Issue 37, pp. 21984-90, 1995 (PubMed).

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