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SUMO1 Antikörper (N-Term)

SUMO1 Reaktivität: Human WB, IF, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB0629 unconjugated
Produktnummer ABIN2845486
  • Target Alle SUMO1 Antikörper anzeigen
    SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))
    Bindungsspezifität
    • 15
    • 15
    • 15
    • 15
    • 10
    • 9
    • 8
    • 8
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term
    Reaktivität
    • 123
    • 89
    • 67
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 125
    • 31
    • 3
    • 1
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 120
    • 44
    Polyklonal
    Konjugat
    • 72
    • 14
    • 12
    • 11
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SUMO1 Antikörper ist unkonjugiert
    Applikation
    • 130
    • 70
    • 50
    • 49
    • 40
    • 39
    • 36
    • 27
    • 16
    • 12
    • 9
    • 8
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B, M, Pig, Rat
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This SUMO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SUMO1.
    Klon
    RB0629
    Isotyp
    Ig Fraction
  • Applikationshinweise
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Saito, Souza, Costa, Meirelles, Gonçalves, Santos, Bressan, McComb, Costello, Whelan, Kobarg: "Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation." in: Journal of proteome research, Vol. 16, Issue 9, pp. 3147-3157, (2018) (PubMed).

    Janer, Werner, Takahashi-Fujigasaki, Daret, Fujigasaki, Takada, Duyckaerts, Brice, Dejean, Sittler: "SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7." in: Human molecular genetics, Vol. 19, Issue 1, pp. 181-95, (2009) (PubMed).

    Ji, Degerny, Vintonenko, Deheuninck, Foveau, Leroy, Coll, Tulasne, Baert, Fafeur: "Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation." in: Oncogene, Vol. 26, Issue 3, pp. 395-406, (2007) (PubMed).

    Bradley, van der Meer, Roodi, Yan, Chandrasekharan, Sun, Mernaugh, Parl: "Carcinogen-induced histone alteration in normal human mammary epithelial cells." in: Carcinogenesis, Vol. 28, Issue 10, pp. 2184-92, (2007) (PubMed).

    Degerny, Monte, Beaudoin, Jaffray, Portois, Hay, de Launoit, Baert: "SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24330-8, (2005) (PubMed).

    Yang, Sharrocks: "SUMO promotes HDAC-mediated transcriptional repression." in: Molecular cell, Vol. 13, Issue 4, pp. 611-7, (2004) (PubMed).

    Ling, Sankpal, Robertson, McNally, Karpova, Robertson: "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription." in: Nucleic acids research, Vol. 32, Issue 2, pp. 598-610, (2004) (PubMed).

    Bailey, OHare: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, (2003) (PubMed).

    Pountney, Huang, Burns, Haan, Thompson, Blumbergs, Gai: "SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease." in: Experimental neurology, Vol. 184, Issue 1, pp. 436-46, (2003) (PubMed).

    Ohshima, Shimotohno: "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50833-42, (2003) (PubMed).

  • Target
    SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))
    Andere Bezeichnung
    SUMO1 (SUMO1 Produkte)
    Synonyme
    DAP1 antikoerper, GMP1 antikoerper, OFC10 antikoerper, PIC1 antikoerper, SENP2 antikoerper, SMT3 antikoerper, SMT3C antikoerper, SMT3H3 antikoerper, UBL1 antikoerper, hm:zeh0670 antikoerper, wu:fb74c02 antikoerper, wu:fd12c02 antikoerper, zgc:65934 antikoerper, zgc:85634 antikoerper, SUMO1 antikoerper, dap1 antikoerper, gmp1 antikoerper, ofc10 antikoerper, pic1 antikoerper, senp2 antikoerper, smt3 antikoerper, smt3c antikoerper, sumo-1 antikoerper, sumo1 antikoerper, ubl1 antikoerper, xsumo-1 antikoerper, xsumo1 antikoerper, ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1 antikoerper, ATSUMO1 antikoerper, F10M23.180 antikoerper, F10M23_180 antikoerper, SMALL UBIQUITIN-LIKE MODIFIER 1 antikoerper, SUM1 antikoerper, SUMO 1 antikoerper, small ubiquitin-like modifier 1 antikoerper, pigSUMO1 antikoerper, SENTRIN antikoerper, SMTP3 antikoerper, SUMO-1 antikoerper, Smt3C antikoerper, Ubl1 antikoerper, small ubiquitin-like modifier 1 antikoerper, small ubiquitin-like modifier 1 S homeolog antikoerper, small ubiquitin-related protein 1 antikoerper, SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) antikoerper, SMT3 suppressor of mif two 3 homolog 1 (yeast) antikoerper, small ubiquitin-like modifier 1 L homeolog antikoerper, Sumo1 antikoerper, SUMO1 antikoerper, sumo1 antikoerper, sumo1.S antikoerper, sumo-1 antikoerper, sumo1.L antikoerper
    Hintergrund
    Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. The SUMO family consists of SUMO1 and closely related homologs SUMO2, SUMO3, and SUMO4. Sumoylation has been shown to regulate a wide range of proteins, including MDM2, PIAS, PML, RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, PARK2, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, CaMK, DNMT3B, TDG, HIF1A, CHD3, EXOSC9, RAD51, and viral targets such as CMV-IE1/2, EBV-BZLF1, and HPV/BPV-E1.
    Molekulargewicht
    11557
    NCBI Accession
    NP_001005781, NP_001005782, NP_003343
    UniProt
    P63165
    Pathways
    M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway
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