RPS6KA6 Antikörper (N-Term)

Produktnummer ABIN2842047

Produktdetails anti-RPS6KA6 Antikörper

Target: RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))

Bindungsspezifität: AA 15-45, N-Term

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPS6KA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human RSK4.

Klon: RB0894

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-RPS6KA6 Antikörper (ABIN2842047)

Sulzmaier, Young-Robbins, Jiang, Geerts, Prechtl, Matter, Kesari, Ramos: "RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics." in: Oncotarget, Vol. 7, Issue 48, pp. 79869-79884, (2018) (PubMed).

Thakur, Sun, Bollig, Wu, Biliran, Banerjee, Sarkar, Liao: "Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 14, pp. 4427-36, (2008) (PubMed).

Yntema, van den Helm, Kissing, van Duijnhoven, Poppelaars, Chelly, Moraine, Fryns, Hamel, Heilbronner, Pander, Brunner, Ropers, Cremers, van Bokhoven: "A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation." in: Genomics, Vol. 62, Issue 3, pp. 332-43, (2000) (PubMed).

Details zu RPS6KA6

Target: RPS6KA6 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 6 (RPS6KA6))

Andere Bezeichnung: RSK4 (RPS6KA6 Produkte)

Synonyme: PP90RSK4 antikoerper, RSK4 antikoerper, 2610524K04Rik antikoerper, RGD1560817 antikoerper, ribosomal protein S6 kinase A6 antikoerper, ribosomal protein S6 kinase polypeptide 6 antikoerper, RPS6KA6 antikoerper, Rps6ka6 antikoerper

Hintergrund: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK). The calcium/calmodulin-dependent kinase (CAMK) group consists of 75 kinases regulated by Ca2+/CaM and close relative family (CAMK, CAMKL, DAPK, MAPKAPK).

Molekulargewicht: 83872

NCBI Accession: NP_055311

UniProt: Q9UK32

Pathways: MAPK Signalweg