AGAP2 Antikörper (AA 981-1080) (Alexa Fluor 594)

Produktnummer ABIN2811560

Produktdetails anti-AGAP2 Antikörper (Alexa Fluor 594)

Target: AGAP2 (ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2))

Bindungsspezifität: AA 981-1080

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AGAP2 Antikörper ist konjugiert mit Alexa Fluor 594

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Centaurin gamma 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu AGAP2

Target: AGAP2 (ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2))

Andere Bezeichnung: Centaurin gamma 1 (AGAP2 Produkte)

Synonyme: zgc:153779 antikoerper, CENTG1 antikoerper, GGAP2 antikoerper, PIKE antikoerper, Centg1 antikoerper, mKIAA0167 antikoerper, Pike antikoerper, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 antikoerper, AGAP2 antikoerper, agap2 antikoerper, Agap2 antikoerper

Hintergrund:

Synonyms: Centaurin gamma 1, ANK repeat and PH domain-containing protein 2, AGAP-2, Agap2, Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, AGAP2_HUMAN, ANK repeat and PH domains 2, Arf GAP with GTP binding protein like, Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2, Arf GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2, Arf-GAP with GTPase, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, centaurin gamma1, Centaurin-gamma-1, Centg1, cnt g1, Cnt-g1, Cnt2, GGAP2, GTP binding and GTPase activating protein 2, GTP-binding and GTPase activating protein 2, GTP-binding and GTPase-activating protein 2, Nuclear GTPase PIKE, Phosphatidylinositol-3-kinase enhancer, Phosphoinositide 3 kinase enhancer, PI3K ENHANCER, PIKE.

Background: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.