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APEX2 Antikörper (AA 301-400) (Alexa Fluor 594)

APEX2 Reaktivität: Ratte, Maus WB Wirt: Kaninchen Polyclonal Alexa Fluor 594
Produktnummer ABIN2809820
  • Target Alle APEX2 Antikörper anzeigen
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    Bindungsspezifität
    • 14
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reaktivität
    • 21
    • 15
    • 14
    Ratte, Maus
    Wirt
    • 34
    • 2
    Kaninchen
    Klonalität
    • 36
    Polyklonal
    Konjugat
    • 13
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser APEX2 Antikörper ist konjugiert mit Alexa Fluor 594
    Applikation
    • 34
    • 17
    • 15
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Maus, Ratte
    Homologie
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human APEX2
    Isotyp
    IgG
    Top Product
    Discover our top product APEX2 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    Andere Bezeichnung
    APEX2 (APEX2 Produkte)
    Synonyme
    APE2 antikoerper, APEXL2 antikoerper, XTH2 antikoerper, ape2 antikoerper, apexl2 antikoerper, xth2 antikoerper, zgc:55889 antikoerper, C430040P13Rik antikoerper, apurinic/apyrimidinic endodeoxyribonuclease 2 antikoerper, APEX nuclease (apurinic/apyrimidinic endonuclease) 2 antikoerper, apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog antikoerper, apurinic/apyrimidinic endonuclease 2 antikoerper, APEX2 antikoerper, apex2 antikoerper, apex2.L antikoerper, Apex2 antikoerper
    Hintergrund

    Synonyms: APE2, XTH2, ZGRF2, APEXL2, DNA-(apurinic or apyrimidinic site) lyase 2, AP endonuclease XTH2, APEX nuclease 2, APEX nuclease-like 2, Apurinic-apyrimidinic endonuclease 2, AP endonuclease 2, APEX2

    Background: Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

    Gen-ID
    27301
    UniProt
    Q9UBZ4
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