AP2A2 Antikörper (AA 21-150) (Alexa Fluor 594)

Produktnummer ABIN2809664

Produktdetails anti-AP2A2 Antikörper (Alexa Fluor 594)

Target: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Bindungsspezifität: AA 21-150

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AP2A2 Antikörper ist konjugiert mit Alexa Fluor 594

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Spezifität: Based on the similarity among the Alpha2-Adaptin proteins, this antibody will bind both AP2A1 and AP2A2.

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AP2A2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu AP2A2

Target: AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))

Andere Bezeichnung: alpha2 Adaptin (AP2A2 Produkte)

Synonyme: MGC99219 antikoerper, ADTAB antikoerper, CLAPA2 antikoerper, HIP-9 antikoerper, HIP9 antikoerper, HYPJ antikoerper, 2410074K14Rik antikoerper, AF006990 antikoerper, AW146353 antikoerper, Adtab antikoerper, C78001 antikoerper, L25 antikoerper, adaptor related protein complex 2 alpha 2 subunit antikoerper, adaptor related protein complex 2 alpha 2 subunit L homeolog antikoerper, adaptor-related protein complex 2, alpha 2 subunit antikoerper, AP2A2 antikoerper, ap2a2.L antikoerper, Ap2a2 antikoerper

Hintergrund:

Synonyms: AP-2 complex subunit alpha-2, 100 kDa coated vesicle protein C, Adaptor protein complex AP-2 subunit alpha-2, Adaptor-related protein complex 2 subunit alpha-2, Alpha-adaptin C, Alpha2-adaptin, Clathrin assembly protein complex 2 alpha-C large chain, Huntingtin yeast partner J, Huntingtin-interacting protein 9, HIP-9, Huntingtin-interacting protein J, Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit, AP2A2, ADTAB, CLAPA2, AP-2 complex subunit alpha-1, 100 kDa coated vesicle protein A, Adaptor protein complex AP-2 subunit alpha-1, Adaptor-related protein complex 2 subunit alpha-1, Alpha-adaptin A, Alpha1-adaptin, Clathrin assembly protein complex 2 alpha-A large chain, Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit, AP2A1, ADTAA, CLAPA1

Background: Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate 100 kDa gene products with similar domain structures (alpha and beta adaptin) and a 50 and 17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.

Gen-ID: 161

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation, SARS-CoV-2 Protein Interaktom