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POLR3C Antikörper (AA 50-80) (Alexa Fluor 350)

POLR3C Reaktivität: Human WB, IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 350
Produktnummer ABIN2809132
  • Target Alle POLR3C Antikörper anzeigen
    POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
    Bindungsspezifität
    • 14
    • 9
    • 8
    • 7
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 50-80
    Reaktivität
    • 47
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 43
    • 4
    Kaninchen
    Klonalität
    • 46
    • 1
    Polyklonal
    Konjugat
    • 20
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser POLR3C Antikörper ist konjugiert mit Alexa Fluor 350
    Applikation
    • 42
    • 21
    • 12
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human POLR3C
    Isotyp
    IgG
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  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
    Andere Bezeichnung
    POLR3C (POLR3C Produkte)
    Synonyme
    rpc3 antikoerper, rpc62 antikoerper, 4933407E01Rik antikoerper, RPC3 antikoerper, RPC62 antikoerper, zgc:56348 antikoerper, polymerase (RNA) III (DNA directed) polypeptide C (62kD) S homeolog antikoerper, RNA polymerase III subunit C antikoerper, polymerase (RNA) III (DNA directed) polypeptide C (62kD) antikoerper, polymerase (RNA) III (DNA directed) polypeptide C antikoerper, polr3c.S antikoerper, POLR3C antikoerper, polr3c antikoerper, Polr3c antikoerper
    Hintergrund

    Synonyms: RPC3, RPC62, DNA-directed RNA polymerase III subunit RPC3, RNA polymerase III subunit C3, DNA-directed RNA polymerase III subunit C, RNA polymerase III 62 kDa subunit, POLR3C

    Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

    Gen-ID
    10623
    UniProt
    Q9BUI4
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