CDKN2A Antikörper (C-Term)

Produktnummer ABIN2797433

Produktdetails anti-CDKN2A Antikörper

Target: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Bindungsspezifität: AA 104-131, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDKN2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Verwendungszweck: Rabbit Anti-Human p16INK4a (C-term E119) Antibody

Immunogen: This p16INK4a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-131 amino acids from the C-terminal region of human p16INK4a.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot, Immunohistochemistry, Flow Cytometry, Immunofluorescence
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50, IF: 1:10-50Western blot analysis of lysate from A2058 cell line, using p16INK4a Antibody (C-term E119) .

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.270 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Details zu CDKN2A

Target: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Andere Bezeichnung: p16INK4a (CDKN2A Produkte)

Synonyme: Arf antikoerper, p16 antikoerper, MTS1 antikoerper, INK4A antikoerper, p19ARF antikoerper, p16Cdkn2a antikoerper, ARF antikoerper, CDK4I antikoerper, CDKN2 antikoerper, CMM2 antikoerper, INK4 antikoerper, MLM antikoerper, MTS-1 antikoerper, P14 antikoerper, P14ARF antikoerper, P16 antikoerper, P16-INK4A antikoerper, P16INK4 antikoerper, P16INK4A antikoerper, P19 antikoerper, P19ARF antikoerper, TP16 antikoerper, ARF-INK4a antikoerper, INK4a-ARF antikoerper, Ink4a/Arf antikoerper, Pctr1 antikoerper, p16(INK4a) antikoerper, p16INK4a antikoerper, p19 antikoerper, cyclin-dependent kinase inhibitor 2A antikoerper, cyclin dependent kinase inhibitor 2A antikoerper, Cdkn2a antikoerper, LOC100731972 antikoerper, LOC100340625 antikoerper, CDKN2A antikoerper

Hintergrund:

Target Description: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Gene Symbol: CDKN2A

Molekulargewicht: 16533 Da

Gen-ID: 1029

UniProt: P42771

Pathways: Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagie, Positive Regulation of Response to DNA Damage Stimulus