Nucleobindin 1 Antikörper (C-Term)

Produktnummer ABIN2792699

Produktdetails anti-Nucleobindin 1 Antikörper

Target: Nucleobindin 1 (NUCB1)

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nucleobindin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PAAHPEGQLK FHPDTDDVPV PAPAGDQKEV DTSEKKLLER LPEVEVPQHL

Kreuzreaktivität: Human

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NUCB1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NUCB1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 461 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Nucleobindin 1 Antikörper (ABIN2792699)

Larkin, Costantino, Seaman, Lavoie: "Calnuc Function in Endosomal Sorting of Lysosomal Receptors." in: Traffic (Copenhagen, Denmark), Vol. 17, Issue 4, pp. 416-32, (2016) (PubMed).

Details zu Nucleobindin 1

Target: Nucleobindin 1 (NUCB1)

Andere Bezeichnung: Nucleobindin-1 (NUCB1 Produkte)

Synonyme: nuc antikoerper, MGC69294 antikoerper, MGC81496 antikoerper, NUCB1 antikoerper, zgc:153192 antikoerper, DKFZp459O1814 antikoerper, B230337F23Rik antikoerper, C77483 antikoerper, Calnuc antikoerper, MTEST82 antikoerper, Nucb antikoerper, CALNUC antikoerper, NUC antikoerper, nucleobindin 1 antikoerper, nucleobindin 1 S homeolog antikoerper, nucb1 antikoerper, nucb1.S antikoerper, NUCB1 antikoerper, Nucb1 antikoerper

Hintergrund: Calnuc or NUCB1 belongs to the nucleobindin family. It is a major calcium-binding protein of the Golgi and is a good Golgi marker. It may be involved in calcium homeostasis. Calnuc also plays roles in regulation of levels of .-amyloid precursor protein (APP) and its proteolytic metabolites to further affect the patho/physiological functions of APP including Alzheimer's disease pathogenesis. Useful for immunohistochemistry and western blot.
Alias Symbols: NUC, CALNUC
Protein Interaction Partner: REL, UBC, MDM2, CTPS2, RAD23B, PRKDC, METTL1, GTF2I, CBS, XPNPEP1, WARS, PTGS2, XPO1, SET, RBL1, MYC, HIVEP1, GNAS, GNAI3, GNAI1, KLC4, PTGS1, NDN, GNAI2, GNAO1, GNAZ,
Protein Size: 461

Molekulargewicht: 51 kDa

Gen-ID: 4924

NCBI Accession: NM_006184, NP_006175

UniProt: Q02818